Epithelium: at the Interface of Innate and Adaptive Immune Responses

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2007 Oct 24

PMID 17949801

Citations 165

Authors

Robert P Schleimer

Atsushi Kato

Robert Kern

Douglas Kuperman

Pedro C Avila

Affiliations

Soon will be listed here.

Abstract

Several diseases of the airways have a strong component of allergic inflammation in their cause, including allergic rhinitis, asthma, polypoid chronic rhinosinusitis, eosinophilic bronchitis, and others. Although the roles played by antigens and pathogens vary, these diseases have in common a pathology that includes marked activation of epithelial cells in the upper airways, the lower airways, or both. Substantial new evidence indicates an important role of epithelial cells as both mediators and regulators of innate immune responses and adaptive immune responses, as well as the transition from innate immunity to adaptive immunity. The purpose of this review is to discuss recent studies that bear on the molecular and cellular mechanisms by which epithelial cells help to shape the responses of dendritic cells, T cells, and B cells and inflammatory cell recruitment in the context of human disease. Evidence will be discussed that suggests that secreted products of epithelial cells and molecules expressed on their cell surfaces can profoundly influence both immunity and inflammation in the airways.

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References

Rogge L, DAmbrosio D, Biffi M, Penna G, Minetti L, Presky D . The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J Immunol. 1998; 161(12):6567-74. View

Rimaniol A, Till S, Garcia G, Capel F, Godot V, Balabanian K . The CX3C chemokine fractalkine in allergic asthma and rhinitis. J Allergy Clin Immunol. 2003; 112(6):1139-46. DOI: 10.1016/j.jaci.2003.09.041. View

Laan M, Cui Z, Hoshino H, Lotvall J, Sjostrand M, Gruenert D . Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 1999; 162(4):2347-52. View

Hieshima K, Kawasaki Y, Hanamoto H, Nakayama T, Nagakubo D, Kanamaru A . CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. J Immunol. 2004; 173(6):3668-75. DOI: 10.4049/jimmunol.173.6.3668. View

Pilette C, Durham S, Vaerman J, Sibille Y . Mucosal immunity in asthma and chronic obstructive pulmonary disease: a role for immunoglobulin A?. Proc Am Thorac Soc. 2005; 1(2):125-35. DOI: 10.1513/pats.2306032. View

Kabesch M, Carr D, Weiland S, von Mutius E . Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. Clin Exp Allergy. 2004; 34(3):340-5. DOI: 10.1111/j.1365-2222.2004.01860.x. View

Chee L, Graham S, Carothers D, Ballas Z . Immune dysfunction in refractory sinusitis in a tertiary care setting. Laryngoscope. 2001; 111(2):233-5. DOI: 10.1097/00005537-200102000-00008. View

McAllister F, Henry A, Kreindler J, Dubin P, Ulrich L, Steele C . Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol. 2005; 175(1):404-12. PMC: 2849297. DOI: 10.4049/jimmunol.175.1.404. View

Stanciu L, Bellettato C, Laza-Stanca V, Coyle A, Papi A, Johnston S . Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines. J Infect Dis. 2006; 193(3):404-12. DOI: 10.1086/499275. View

10.

Propst S, Denson R, ROTHSTEIN E, Estell K, Schwiebert L . Proinflammatory and Th2-derived cytokines modulate CD40-mediated expression of inflammatory mediators in airway epithelia: implications for the role of epithelial CD40 in airway inflammation. J Immunol. 2000; 165(4):2214-21. DOI: 10.4049/jimmunol.165.4.2214. View

11.

Zheng Y, Danilenko D, Valdez P, Kasman I, Eastham-Anderson J, Wu J . Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2006; 445(7128):648-51. DOI: 10.1038/nature05505. View

12.

Sung S, Fu S, Rose Jr C, Gaskin F, Ju S, Beaty S . A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol. 2006; 176(4):2161-72. DOI: 10.4049/jimmunol.176.4.2161. View

13.

Wark P, Johnston S, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V . Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005; 201(6):937-47. PMC: 2213100. DOI: 10.1084/jem.20041901. View

14.

Brandtzaeg P, Carlsen H, Halstensen T . The B-cell system in inflammatory bowel disease. Adv Exp Med Biol. 2006; 579:149-67. DOI: 10.1007/0-387-33778-4_10. View

15.

John A, Thomas M, Berlin A, Lukacs N . Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. Am J Pathol. 2005; 166(2):345-53. PMC: 1602329. DOI: 10.1016/S0002-9440(10)62258-4. View

16.

Soumelis V, Reche P, Kanzler H, Yuan W, Edward G, Homey B . Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002; 3(7):673-80. DOI: 10.1038/ni805. View

17.

Yoshida T, Usui A, Kusumi T, Inafuku S, Sugiyama T, Koide N . A quantitative analysis of cedar pollen-specific immunoglobulins in nasal lavage supported the local production of specific IgE, not of specific IgG. Microbiol Immunol. 2005; 49(6):529-34. DOI: 10.1111/j.1348-0421.2005.tb03758.x. View

18.

Kato A, Favoreto Jr S, Avila P, Schleimer R . TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol. 2007; 179(2):1080-7. PMC: 2220044. DOI: 10.4049/jimmunol.179.2.1080. View

19.

Reibman J, Hsu Y, Chen L, Bleck B, Gordon T . Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol. 2003; 28(6):648-54. DOI: 10.1165/rcmb.2002-0095OC. View

20.

Lucas A, Chadwick N, Warren B, Jewell D, Gordon S, Powrie F . The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol. 2001; 158(3):855-66. PMC: 1850344. DOI: 10.1016/S0002-9440(10)64034-5. View