Advanced Glycation End Products, Diabetes and Ageing

Overview

Journal Z Gerontol Geriatr

Publisher Springer

Specialty Geriatrics

Date 2007 Oct 19

PMID 17943238

Citations 56

Authors

N Nass

B Bartling

A Navarrete Santos

R J Scheubel

J Borgermann

R E Silber

A Simm

Affiliations

Soon will be listed here.

Abstract

Advanced glycation end products (AGEs) are formed in vivo by a non-enzymatic reaction of proteins with carbohydrates and accumulate in many tissues during ageing. They are discussed as being responsible for many age- and diabetes-related diseases. On the other hand, AGEs are formed by the heating of food and are taken up by the nutrition. The contribution of endogenously formed versus exogenous intake of AGEs to age-related diseases is still under discussion.

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References

Hodgkinson C, Mander A, Sale G . Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Biochem J. 2005; 388(Pt 3):785-93. PMC: 1183457. DOI: 10.1042/BJ20041845. View

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I . Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Cell. 2006; 124(2):275-86. DOI: 10.1016/j.cell.2005.11.024. View

Schmidt A, Hori O, Chen J, Li J, Crandall J, Zhang J . Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of.... J Clin Invest. 1995; 96(3):1395-403. PMC: 185762. DOI: 10.1172/JCI118175. View

Stadler K, Jenei V, Somogyi A, Jakus J . Beneficial effects of aminoguanidine on the cardiovascular system of diabetic rats. Diabetes Metab Res Rev. 2004; 21(2):189-96. DOI: 10.1002/dmrr.501. View

Dyer D, Dunn J, Thorpe S, Lyons T, McCance D, Baynes J . Accumulation of Maillard reaction products in skin collagen in diabetes and aging. Ann N Y Acad Sci. 1992; 663:421-2. DOI: 10.1111/j.1749-6632.1992.tb38687.x. View

Shanmugam N, Kim Y, Lanting L, Natarajan R . Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products. J Biol Chem. 2003; 278(37):34834-44. DOI: 10.1074/jbc.M302828200. View

Li S, Liu Y, Sigmon V, McCort A, Ren J . High-fat diet enhances visceral advanced glycation end products, nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase activation and apoptosis. Diabetes Obes Metab. 2005; 7(4):448-54. DOI: 10.1111/j.1463-1326.2004.00387.x. View

Olshansky S, Passaro D, Hershow R, Layden J, Carnes B, Brody J . A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005; 352(11):1138-45. DOI: 10.1056/NEJMsr043743. View

Sell D, Kleinman N, Monnier V . Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice. FASEB J. 2000; 14(1):145-56. DOI: 10.1096/fasebj.14.1.145. View

10.

Zill H, Bek S, Hofmann T, Huber J, Frank O, Lindenmeier M . RAGE-mediated MAPK activation by food-derived AGE and non-AGE products. Biochem Biophys Res Commun. 2002; 300(2):311-5. DOI: 10.1016/s0006-291x(02)02856-5. View

11.

Brownlee M, Vlassara H, Cerami A . Nonenzymatic glycosylation products on collagen covalently trap low-density lipoprotein. Diabetes. 1985; 34(9):938-41. DOI: 10.2337/diab.34.9.938. View

12.

Veiga da-Cunha M, Jacquemin P, Delpierre G, Godfraind C, Theate I, Vertommen D . Increased protein glycation in fructosamine 3-kinase-deficient mice. Biochem J. 2006; 399(2):257-64. PMC: 1609913. DOI: 10.1042/BJ20060684. View

13.

Hernebring M, Brolen G, Aguilaniu H, Semb H, Nystrom T . Elimination of damaged proteins during differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006; 103(20):7700-5. PMC: 1472508. DOI: 10.1073/pnas.0510944103. View

14.

Bolton W, Cattran D, Williams M, Adler S, Appel G, Cartwright K . Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol. 2003; 24(1):32-40. DOI: 10.1159/000075627. View

15.

Westwood M, McLellan A, Thornalley P . Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor. J Biol Chem. 1994; 269(51):32293-8. View

16.

Schleicher E, Wagner E, Nerlich A . Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest. 1997; 99(3):457-68. PMC: 507819. DOI: 10.1172/JCI119180. View

17.

Sato T, Shimogaito N, Wu X, Kikuchi S, Yamagishi S, Takeuchi M . Toxic advanced glycation end products (TAGE) theory in Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2006; 21(3):197-208. PMC: 10833335. DOI: 10.1177/1533317506289277. View

18.

Ahmed N, Thornalley P . Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo. Ann N Y Acad Sci. 2005; 1043:260-6. DOI: 10.1196/annals.1333.031. View

19.

BUNN H, Higgins P . Reaction of monosaccharides with proteins: possible evolutionary significance. Science. 1981; 213(4504):222-4. DOI: 10.1126/science.12192669. View

20.

Vlassara H, Fuh H, Donnelly T, Cybulsky M . Advanced glycation endproducts promote adhesion molecule (VCAM-1, ICAM-1) expression and atheroma formation in normal rabbits. Mol Med. 1995; 1(4):447-56. PMC: 2229997. View