Telomere Shortening and Ageing

Overview

Journal Z Gerontol Geriatr

Publisher Springer

Specialty Geriatrics

Date 2007 Oct 19

PMID 17943234

Citations 60

Authors

H Jiang

Z Ju

K L Rudolph

Affiliations

Soon will be listed here.

Abstract

Telomeres form the ends of human chromosomes. Telomeres shorten with each round of cell division and this mechanism limits proliferation of human cells to a finite number of cell divisions by inducing replicative senescence, differentiation, or apoptosis. Telomere shortening can act as a tumor suppressor. However, as a downside, there is growing evidence indicating that telomere shortening also limits stem cell function, regeneration, and organ maintenance during ageing. Moreover, telomere shortening during ageing and disease is associated with increasing cancer risk. In this review we summarize our current knowledge on the role of telomere shortening in human ageing, chronic diseases, and cancer.

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References

Greider C . Telomere length regulation. Annu Rev Biochem. 1996; 65:337-65. DOI: 10.1146/annurev.bi.65.070196.002005. View

Brouilette S, Moore J, McMahon A, Thompson J, Ford I, Shepherd J . Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007; 369(9556):107-14. DOI: 10.1016/S0140-6736(07)60071-3. View

Blackburn E . Switching and signaling at the telomere. Cell. 2001; 106(6):661-73. DOI: 10.1016/s0092-8674(01)00492-5. View

Nakamura K, Izumiyama-Shimomura N, Sawabe M, Arai T, Aoyagi Y, Fujiwara M . Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol. 2002; 119(5):1014-9. DOI: 10.1046/j.1523-1747.2002.19523.x. View

Artandi S, Chang S, Lee S, Alson S, Gottlieb G, Chin L . Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 2000; 406(6796):641-5. DOI: 10.1038/35020592. View

Tsakiri K, Cronkhite J, Kuan P, Xing C, Raghu G, Weissler J . Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A. 2007; 104(18):7552-7. PMC: 1855917. DOI: 10.1073/pnas.0701009104. View

Panossian L, Porter V, Valenzuela H, Zhu X, Reback E, Masterman D . Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging. 2002; 24(1):77-84. DOI: 10.1016/s0197-4580(02)00043-x. View

Lingner J, Cooper J, Cech T . Telomerase and DNA end replication: no longer a lagging strand problem?. Science. 1995; 269(5230):1533-4. DOI: 10.1126/science.7545310. View

Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U . Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology. 2007; 132(4):1465-75. DOI: 10.1053/j.gastro.2007.01.045. View

10.

Saretzki G, von Zglinicki T . Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci. 2002; 959:24-9. DOI: 10.1111/j.1749-6632.2002.tb02079.x. View

11.

Boukamp P . Skin aging: a role for telomerase and telomere dynamics?. Curr Mol Med. 2005; 5(2):171-7. DOI: 10.2174/1566524053586644. View

12.

Young N . Pathophysiologic mechanisms in acquired aplastic anemia. Hematology Am Soc Hematol Educ Program. 2006; :72-7. DOI: 10.1182/asheducation-2006.1.72. View

13.

dAdda di Fagagna F, Reaper P, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T . A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003; 426(6963):194-8. DOI: 10.1038/nature02118. View

14.

Martin-Ruiz C, Dickinson H, Keys B, Rowan E, Kenny R, von Zglinicki T . Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol. 2006; 60(2):174-80. DOI: 10.1002/ana.20869. View

15.

de Lange T . T-loops and the origin of telomeres. Nat Rev Mol Cell Biol. 2004; 5(4):323-9. DOI: 10.1038/nrm1359. View

16.

Djojosubroto M, Choi Y, Lee H, Rudolph K . Telomeres and telomerase in aging, regeneration and cancer. Mol Cells. 2003; 15(2):164-75. View

17.

Zimmermann S, Martens U . Telomere dynamics in hematopoietic stem cells. Curr Mol Med. 2005; 5(2):179-85. DOI: 10.2174/1566524053586608. View

18.

Wiemann S, Satyanarayana A, Tsahuridu M, Tillmann H, Zender L, Klempnauer J . Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J. 2002; 16(9):935-42. DOI: 10.1096/fj.01-0977com. View

19.

Vaziri H, Dragowska W, Allsopp R, Thomas T, Harley C, Lansdorp P . Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A. 1994; 91(21):9857-60. PMC: 44916. DOI: 10.1073/pnas.91.21.9857. View

20.

Choudhury A, Ju Z, Djojosubroto M, Schienke A, Lechel A, Schaetzlein S . Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 2006; 39(1):99-105. DOI: 10.1038/ng1937. View