Specialization and Evolution of Endogenous Small RNA Pathways

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2007 Oct 19

PMID 17943195

Citations 288

Authors

Elisabeth J Chapman

James C Carrington

Affiliations

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Abstract

The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.

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