[Adaptive Designs for Clinical Trial]

Objective: In order to provide readers with general concepts and methodology on adaptive designs for clinical trial.

Methods: Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.

Results: The relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced.

Conclusion: Adaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.