Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Overview

Journal Ultrasound Med Biol

Specialty Radiology

Date 2007 Oct 16

PMID 17935872

Citations 43

Authors

Kevin J Haworth

J Brian Fowlkes

Paul L Carson

Oliver D Kripfgans

Affiliations

Soon will be listed here.

Abstract

We report on the first experiments demonstrating the transcranial acoustic formation of stable gas bubbles that can be used for transcranial ultrasound aberration correction. It is demonstrated that the gas bubbles can be formed transcranially by phase-transitioning single, superheated, micron-size, liquid dodecafluoropentane droplets with ultrasound, a process known as acoustic droplet vaporization (ADV). ADV was performed at 550 kHz, where the skull is less attenuating and aberrating, allowing for higher-amplitudes to be reached at the focus. Additionally, it is demonstrated that time-reversal focusing at 1 MHz can be used to correct for transcranial aberrations with a single gas bubble acting as a point beacon. Aberration correction was performed using a synthetic aperture approach and verified by the realignment of the scattered waveforms. Under the conditions described below, time-reversal aberration correction using gas bubbles resulted in a gain of 1.9 +/- 0.3 in an introduced focusing factor. This is a small fraction of the gain anticipated from complete transmit-receive of a fully-populated two-dimensional array with sub-wavelength elements. (E-mail: khaworth@umich.edu).

Citing Articles

Aberration correction in abdominal histotripsy.

Yeats E, Hall T Int J Hyperthermia. 2023; 40(1):2266594.

PMID: 37813397 PMC: 10637766. DOI: 10.1080/02656736.2023.2266594.

Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction.

Preston C, Alvarez A, Allard M, Barragan A, Witte R IEEE Trans Ultrason Ferroelectr Freq Control. 2023; 70(8):854-864.

PMID: 37405897 PMC: 10493188. DOI: 10.1109/TUFFC.2023.3292595.

Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse.

Yeats E, Lu N, Sukovich J, Xu Z, Hall T Ultrasound Med Biol. 2023; 49(5):1182-1193.

PMID: 36759271 PMC: 10082475. DOI: 10.1016/j.ultrasmedbio.2023.01.004.

In Vivo Aberration Correction for Transcutaneous HIFU Therapy Using a Multielement Array.

Thomas G, Khokhlova T, Sapozhnikov O, Wang Y, Totten S, Khokhlova V IEEE Trans Ultrason Ferroelectr Freq Control. 2022; 69(10):2955-2964.

PMID: 35981067 PMC: 9714798. DOI: 10.1109/TUFFC.2022.3200309.

Applications of focused ultrasound in the brain: from thermoablation to drug delivery.

Meng Y, Hynynen K, Lipsman N Nat Rev Neurol. 2020; 17(1):7-22.

PMID: 33106619 DOI: 10.1038/s41582-020-00418-z.

References

Fink M . Time reversal of ultrasonic fields. I. Basic principles. IEEE Trans Ultrason Ferroelectr Freq Control. 1992; 39(5):555-66. DOI: 10.1109/58.156174. View

Kripfgans O, Fowlkes J, Miller D, Eldevik O, Carson P . Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000; 26(7):1177-89. DOI: 10.1016/s0301-5629(00)00262-3. View

Hynynen K, McDannold N, Clement G, Jolesz F, Zadicario E, Killiany R . Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Eur J Radiol. 2006; 59(2):149-56. DOI: 10.1016/j.ejrad.2006.04.007. View

Kripfgans O, Orifici C, Carson P, Ives K, Eldevik O, Fowlkes J . Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: a kidney study. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 52(7):1101-10. DOI: 10.1109/tuffc.2005.1503996. View

Flax S, ODonnell M . Phase-aberration correction using signals from point reflectors and diffuse scatterers: basic principles. IEEE Trans Ultrason Ferroelectr Freq Control. 1988; 35(6):758-67. DOI: 10.1109/58.9333. View

Fry F, Barger J . Acoustical properties of the human skull. J Acoust Soc Am. 1978; 63(5):1576-90. DOI: 10.1121/1.381852. View

White P, Clement G, Hynynen K . Longitudinal and shear mode ultrasound propagation in human skull bone. Ultrasound Med Biol. 2006; 32(7):1085-96. PMC: 1560344. DOI: 10.1016/j.ultrasmedbio.2006.03.015. View

Clement G, Hynynen K . Correlation of ultrasound phase with physical skull properties. Ultrasound Med Biol. 2002; 28(5):617-24. DOI: 10.1016/s0301-5629(02)00503-3. View

Psychoudakis D, Fowlkes J, Volakis J, Carson P . Potential of microbubbles for use as point targets in phase aberration correction. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 51(12):1639-48. DOI: 10.1109/tuffc.2004.1386681. View

10.

Yin X, Hynynen K . A numerical study of transcranial focused ultrasound beam propagation at low frequency. Phys Med Biol. 2005; 50(8):1821-36. DOI: 10.1088/0031-9155/50/8/013. View

11.

Pernot M, Aubry J, Tanter M, Thomas J, Fink M . High power transcranial beam steering for ultrasonic brain therapy. Phys Med Biol. 2003; 48(16):2577-89. PMC: 3002099. DOI: 10.1088/0031-9155/48/16/301. View

12.

Sun J, Hynynen K . Focusing of therapeutic ultrasound through a human skull: a numerical study. J Acoust Soc Am. 1998; 104(3 Pt 1):1705-15. DOI: 10.1121/1.424383. View

13.

Giesecke T, Hynynen K . Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound Med Biol. 2003; 29(9):1359-65. DOI: 10.1016/s0301-5629(03)00980-3. View

14.

Zhao D, Trahey G . Comparisons of image quality factors for phase aberration correction with diffuse and point targets: theory and experiments. IEEE Trans Ultrason Ferroelectr Freq Control. 1991; 38(2):125-32. DOI: 10.1109/58.68469. View

15.

Lo A, Kripfgans O, Carson P, Rothman E, Fowlkes J . Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. IEEE Trans Ultrason Ferroelectr Freq Control. 2007; 54(5):933-46. DOI: 10.1109/tuffc.2007.339. View

16.

Kripfgans O, Fowlkes J, Woydt M, Eldevik O, Carson P . In vivo droplet vaporization for occlusion therapy and phase aberration correction. IEEE Trans Ultrason Ferroelectr Freq Control. 2002; 49(6):726-38. DOI: 10.1109/tuffc.2002.1009331. View

17.

Sun J, Hynynen K . The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area. J Acoust Soc Am. 1999; 105(4):2519-27. DOI: 10.1121/1.426863. View

18.

Kripfgans O, Fabiilli M, Carson P, Fowlkes J . On the acoustic vaporization of micrometer-sized droplets. J Acoust Soc Am. 2004; 116(1):272-81. DOI: 10.1121/1.1755236. View

19.

White J, Clement G, Hynynen K . Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 52(9):1518-22. DOI: 10.1109/tuffc.2005.1516024. View

20.

Lang S . Ultrasonic method for measuring elastic coefficients of bone and results on fresh and dried bovine bones. IEEE Trans Biomed Eng. 1970; 17(2):101-5. DOI: 10.1109/tbme.1970.4502706. View