S-adenosylmethionine As a Biomarker for the Early Detection of Lung Cancer

Overview

Journal Chest

Publisher Elsevier

Specialty Pulmonary Medicine

Date 2007 Oct 16

PMID 17934114

Citations 13

Authors

Alissa K Greenberg

Binaya Rimal

Kevin Felner

Subooha Zafar

Jerry Hung

Ellen Eylers

Brendan Phalan

Meng Zhang

Judith D Goldberg

Bernard Crawford

William N Rom

David Naidich

Salim Merali

Affiliations

Soon will be listed here.

Abstract

Background: S-Adenosylmethionine (AdoMet) is a major methyl donor for transmethylation reactions and propylamine donor for the biosynthesis of polyamines in biological systems, and therefore may play a role in lung cancer development. We hypothesized that AdoMet levels were elevated in patients with lung cancer and may prove useful as a biomarker for early lung cancer.

Methods: High-performance liquid chromatography was used to analyze plasma AdoMet levels in triplicate samples from 68 patients. This included 13 patients with lung cancer, 33 smokers with benign lung disease, and 22 healthy nonsmokers. The three groups of subjects were compared with respect to the distribution of demographic and disease characteristics and AdoMet levels. Distributions were examined using summary statistics and box plots, and nonparametric analysis of variance procedures.

Results: Serum AdoMet levels were elevated in patients with lung cancer as compared to smokers with benign lung disorders and healthy nonsmokers. There were no significant correlations between AdoMet levels and tumor cell types, nodule size, or other demographic variables.

Conclusions: Our data demonstrate that plasma levels of AdoMet are significantly elevated in patients with lung cancer. Plasma AdoMet levels may prove to be a useful tool for the diagnosis of early lung cancer, in combination with chest CT. Registered at: clinicaltrials.gov (NCT00301119).

Citing Articles

S-Adenosylmethionine: A Multifaceted Regulator in Cancer Pathogenesis and Therapy.

Fernandez-Ramos D, Lopitz-Otsoa F, Lu S, Mato J Cancers (Basel). 2025; 17(3).

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Exploring the Potential of Non-Coding RNAs as Liquid Biopsy Biomarkers for Lung Cancer Screening: A Literature Review.

Garbo E, Del Rio B, Ferrari G, Cani M, Napoli V, Bertaglia V Cancers (Basel). 2023; 15(19).

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Study of the Relationship Between Serum Amino Acid Metabolism and Lymph Node Metastasis in Patients with Colorectal Cancer.

Liu J, Wang J, Ma X, Feng Y, Chen Y, Wang Y Onco Targets Ther. 2020; 13:10287-10296.

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FOXP3 promotes colorectal carcinoma liver metastases by evaluating MMP9 expression via regulating S-adenosylmethionine metabolism.

Wang Z, Zhang J Ann Transl Med. 2020; 8(9):592.

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Mutations in the S-Adenosylmethionine Synthetase Genes and Differentially Affect Genome Stability in .

Hoffert K, Higginbotham K, Gibson J, Oehrle S, Strome E Genetics. 2019; 213(1):97-112.

PMID: 31320408 PMC: 6727793. DOI: 10.1534/genetics.119.302435.

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