The TolC-like Protein of Neisseria Meningitidis is Required for Extracellular Production of the Repeats-in-toxin Toxin FrpC but Not for Resistance to Antimicrobials Recognized by the Mtr Efflux Pump System

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2007 Oct 10

PMID 17923520

Citations 7

Authors

Nazia Kamal

Corinne Rouquette-Loughlin

William M Shafer

Affiliations

Soon will be listed here.

Abstract

A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally replace the MtrE protein as the outer membrane protein channel for drug export by the MtrC-MtrD-MtrE efflux pump.

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