Histopathological Criteria for the Diagnosis of Abdominal Angiostrongyliasis

Overview

Journal Parasitol Res

Specialty Parasitology

Date 1991 Jan 1

PMID 1792232

Citations 13

Authors

C Graeff-Teixeira

H L Lenzi

Affiliations

Soon will be listed here.

Abstract

An increasing number of cases of abdominal angiostrongyliasis have recently been diagnosed in southern Brazil. A comparative study of 19 confirmed cases and 15 suspected cases was undertaken to review the anatomo-pathology of the disease and to establish histopathological criteria for its diagnosis. The results were similar in both groups, except for the identification of the worm in the confirmed cases. Macroscopic features comprised two types: a predominant thickening of the intestinal wall (pseudo-neoplastic pattern) and a congestive necrotic lesion (ischemic-congestive pattern). Microscopically, three fundamental histopathological findings were detected: (1) a massive infiltration of eosinophils in all layers of the intestinal wall, (2) a granulomatous reaction and (3) eosinophilic vasculitis affecting arteries, veins, lymphatics and capillaries. We conclude that observation of this histopathological triplet excludes other causes of "eosinophilic gastroenteritis" and establishes the diagnosis of probable abdominal angiostrongyliasis.

Citing Articles

Real-time qPCR coupled with high-resolution melting curve analysis for the detection of the internal transcribed spacer 1 of Angiostrongylus costaricensis.

Quesada J, Alfaro-Segura P, Mata-Somarribas C, Alger J, Toledo M, Ramos de Souza J Parasitol Res. 2024; 123(9):312.

PMID: 39218957 DOI: 10.1007/s00436-024-08327-6.

Diagnostic criteria and case definitions for abdominal angiostrongyliasis: a systematic review from the Brazilian experience.

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Case Report: Abdominal Angiostrongyliasis in the Amazon of Ecuador.

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PMID: 35378509 PMC: 9128692. DOI: 10.4269/ajtmh.21-1057.

Abdominal angiostrongyliasis in the Americas: fifty years since the discovery of a new metastrongylid species, Angiostrongylus costaricensis.

Rojas A, Maldonado-Junior A, Mora J, Morassutti A, Rodriguez R, Solano-Barquero A Parasit Vectors. 2021; 14(1):374.

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Abdominal angiostrongyliasis can be diagnosed with a immunochromatographic rapid test with recombinant galactin from Angiostrongylus cantonensis.

Graeff-Teixeira C, Pascoal V, Rodriguez R, Morassutti A, Intapan P, Maleewong W Mem Inst Oswaldo Cruz. 2020; 115:e200201.

PMID: 32965330 PMC: 7508286. DOI: 10.1590/0074-02760200201.

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