The Progesterone Receptor PROGINS Polymorphism is Not Related to Oxidative Stress Factors in Women with Polycystic Ovary Syndrome

Overview

Journal Cardiovasc Diabetol

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
Endocrinology

Date 2007 Oct 9

PMID 17919323

Citations 3

Authors

Muammer Karadeniz

Mehmet Erdogan

Afig Berdeli

Sadik Tamsel

Fusun Saygili

Candeger Yilmaz

Affiliations

Soon will be listed here.

Abstract

Background: Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS.

Methods: Ninety-five young women with PCOS and 99 healthy control women were included in our study. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin and PROGINS polymorphism genetic study.

Results: In PROGINS polymorphism results; in both control and the patient groups T1/T1 has been detected in high levels. But for genotype (p = 0.178) and allele (p = 0.555) frequencies both of the groups give similar results. Statistically significant difference has been detected on serum FSH levels for T1/T1 genotype according to T2/T2 genotype.

Conclusion: No relation has been detected between the inflammatory and oxidative stress factors, and PROGINS polymorphism alleles. This may be because the PCOS patients are young and their BMI means are normal and their CIMT and oxidative stress markers are like healthy women.

Citing Articles

Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystıc ovary syndrome.

Karadeniz M, Erdogan M, Ayhan Z, Yalcin M, Olukman M, Cetinkalp S Lipids Health Dis. 2011; 10:193.

PMID: 22035022 PMC: 3219737. DOI: 10.1186/1476-511X-10-193.

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.

Escobar-Morreale H, Luque-Ramirez M, Gonzalez F Fertil Steril. 2010; 95(3):1048-58.e1-2.

PMID: 21168133 PMC: 3079565. DOI: 10.1016/j.fertnstert.2010.11.036.

Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey.

Cetinkalp S, Karadeniz M, Erdogan M, Zengi A, Cetintas V, Tetik A J Assist Reprod Genet. 2008; 26(1):1-6.

PMID: 19057990 PMC: 2649336. DOI: 10.1007/s10815-008-9280-8.

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