Respiratory Dendritic Cells: Mediators of Tolerance and Immunity

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2007 Oct 6

PMID 17917061

Citations 6

Authors

Ryan A Langlois

Kevin L Legge

Affiliations

Soon will be listed here.

Abstract

The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.

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