The Important Role of Lipid Peroxidation Processes in Aging and Age Dependent Diseases

Overview

Journal Mol Biotechnol

Publisher Springer

Specialties Biotechnology
Molecular Biology

Date 2007 Oct 5

PMID 17914157

Citations 19

Authors

Gerhard Spiteller

Affiliations

Soon will be listed here.

Abstract

Any change in the cell membrane structure activates lipoxygenases (LOX). LOX transform polyunsaturated fatty acids (PUFAs) to lipidhydroperoxide molecules (LOOHs). When cells are severely wounded, this physiological process switches to a non-enzymatic lipid peroxidation (LPO) process producing LOO* radicals. These oxidize nearly all-biological molecules such as lipids, sugars, and proteins. The LOO* induced degradations proceed by transfer of the radicals from cell to cell like an infection. The chemical reactions induced by LO* and LOO* radicals seem to be responsible for aging and induction of age dependent diseases.Alternatively, LO* and LOO* radicals are generated by frying of fats and involve cholesterol-PUFA esters and thus induce atherogenesis. Plants and algae are exposed to LOO* radicals generating radiation. In order to remove LOO* radicals, plants and algae transform PUFAs to furan fatty acids, which are incorporated after consumption of vegetables into mammalian tissues where they act as excellent scavengers of LOO* and LO* radicals.

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References

Spiteller G . Furan fatty acids: occurrence, synthesis, and reactions. Are furan fatty acids responsible for the cardioprotective effects of a fish diet?. Lipids. 2005; 40(8):755-71. DOI: 10.1007/s11745-005-1438-5. View

Davis T, Gao L, Yin H, Morrow J, Porter N . In vivo and in vitro lipid peroxidation of arachidonate esters: the effect of fish oil omega-3 lipids on product distribution. J Am Chem Soc. 2006; 128(46):14897-904. DOI: 10.1021/ja064399o. View

GLASS R, Krick T, Sand D, Rahn C, Schlenk H . Furanoid fatty acids from fish lipids. Lipids. 1975; 10(11):695-702. DOI: 10.1007/BF02532763. View

de Lorgeril M, Richard M, Arnaud J, Boissonnat P, Guidollet J, Dureau G . Lipid peroxides and antioxidant defenses in accelerated transplantation-associated coronary arteriosclerosis. Am Heart J. 1993; 125(4):974-80. DOI: 10.1016/0002-8703(93)90103-g. View

Gardner H . Oxygen radical chemistry of polyunsaturated fatty acids. Free Radic Biol Med. 1989; 7(1):65-86. DOI: 10.1016/0891-5849(89)90102-0. View

Suzuki M, Yamamoto D, Suzuki T, Fujii M, Suzuki N, Fujishiro M . High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate. Life Sci. 2006; 80(3):200-4. DOI: 10.1016/j.lfs.2006.09.002. View

Ross R, Glomset J . Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973; 180(4093):1332-9. DOI: 10.1126/science.180.4093.1332. View

Spiteller P, Kern W, Reiner J, Spiteller G . Aldehydic lipid peroxidation products derived from linoleic acid. Biochim Biophys Acta. 2001; 1531(3):188-208. DOI: 10.1016/s1388-1981(01)00100-7. View

Youhnovski N, Schulz D, Schwarz C, Spiteller G, Schubert K . Determination of hydroxyoctadecadienoic acids. Z Naturforsch C J Biosci. 2003; 58(3-4):268-76. DOI: 10.1515/znc-2003-3-422. View

10.

Batna A, Spiteller G . Oxidation of furan fatty acids by soybean lipoxygenase-1 in the presence of linoleic acid. Chem Phys Lipids. 1994; 70(2):179-85. DOI: 10.1016/0009-3084(94)90085-x. View

11.

Weber L, Boll M, Stampfl A . Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003; 33(2):105-36. DOI: 10.1080/713611034. View

12.

Weisser M, Spiteller G . Increase of aldehydic compounds derived from plasmalogens in the brain of aged cattle. Chem Phys Lipids. 1996; 82(2):173-8. DOI: 10.1016/0009-3084(96)02588-1. View

13.

Goldstein J, Brown M . The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem. 1977; 46:897-930. DOI: 10.1146/annurev.bi.46.070177.004341. View

14.

Batna A, Scheinkonig J, Spiteller G . The occurrence of furan fatty acids in Isochrysis sp. and Phaeodactylum tricornutum. Biochim Biophys Acta. 1993; 1166(2-3):171-6. DOI: 10.1016/0005-2760(93)90093-o. View

15.

Milne G, Morrow J . Isoprostanes and related compounds: update 2006. Antioxid Redox Signal. 2006; 8(7-8):1379-84. DOI: 10.1089/ars.2006.8.1379. View

16.

Grundy S . United States Cholesterol Guidelines 2001: expanded scope of intensive low-density lipoprotein-lowering therapy. Am J Cardiol. 2001; 88(7B):23J-27J. DOI: 10.1016/s0002-9149(01)01931-2. View

17.

Greenberg J . PROGRAMMED CELL DEATH IN PLANT-PATHOGEN INTERACTIONS. Annu Rev Plant Physiol Plant Mol Biol. 1997; 48:525-545. DOI: 10.1146/annurev.arplant.48.1.525. View

18.

Jira W, Spiteller G, CARSON W, Schramm A . Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients. Chem Phys Lipids. 1998; 91(1):1-11. DOI: 10.1016/s0009-3084(97)00095-9. View

19.

Richardson D, Regino C, Yao H, Johnson J . Methionine oxidation by peroxymonocarbonate, a reactive oxygen species formed from CO2/bicarbonate and hydrogen peroxide. Free Radic Biol Med. 2003; 35(12):1538-50. DOI: 10.1016/j.freeradbiomed.2003.08.019. View

20.

BOYER R, Litts D, Kostishak J, Wijesundera R, GUNSTONE F . The action of lipoxygenase-1 on furan derivatives. Chem Phys Lipids. 1979; 25(3):237-46. DOI: 10.1016/0009-3084(79)90109-9. View