Cardiorespiratory Responses During Three Repeated Incremental Exercise Tests in Sickle Cell Trait Carriers

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2007 Oct 3

PMID 17909842

Citations 6

Authors

Laurent Marlin

Philippe Connes

Sophie Antoine-Jonville

Julien Tripette

Mona Montout-Hedreville

Alain Sanouiller

Maryse Etienne-Julan

Olivier Hue

Affiliations

Soon will be listed here.

Abstract

This study investigated the cardioventilatory responses during heavy exercise in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group). Eight SCTc and six control subjects repeated three incremental exercise tests (Iet) separated by 10-min recoveries. Cardioventilatory parameters were analyzed at rest and during the first and third Iet. No significant difference in the ventilatory parameters [notably, maximal oxygen uptake (VO2max) and the ventilatory thresholds] was observed between the two groups. The time course of power output showed a significant difference between the first and third Iet from 80% of VO2max to VO2max (P < 0.05) in both groups. In conclusion, SCTc exhibited normal ventilatory responses during three successive Iet, which strongly suggests that this population, despite the presence of HbS in their red blood cells, is not limited during this type of aerobic exercise.

Citing Articles

The relationship between hemoglobin and [Formula: see text]: A systematic review and meta-analysis.

Webb K, Gorman E, Morkeberg O, Klassen S, Regimbal R, Wiggins C PLoS One. 2023; 18(10):e0292835.

PMID: 37824583 PMC: 10569622. DOI: 10.1371/journal.pone.0292835.

Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise.

Messonnier L, Oyono-Enguelle S, Vincent L, Dubouchaud H, Chatel B, Sanchez H Nutrients. 2022; 14(3).

PMID: 35276859 PMC: 8838817. DOI: 10.3390/nu14030501.

Strenuous exercise in warm environment is associated with improved microvascular function in sickle cell trait.

Reminy K, Ngo Sock E, Romana M, Connes P, Ravion S, Henri S Eur J Appl Physiol. 2021; 122(1):185-197.

PMID: 34633508 DOI: 10.1007/s00421-021-04821-2.

Effects of α Deletion and Sickle-Cell Trait on Ventilatory and Hemodynamic Responses to Maximum Exercise in Young Saudi Females.

Asoom L, Al Makhaita M, Rafique N, Al Afandi D, Al Otaibi W, Alsuwat H J Blood Med. 2020; 11:371-378.

PMID: 33117023 PMC: 7585821. DOI: 10.2147/JBM.S272905.

Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA.

Liem R, Chan C, Vu T, Fornage M, Thompson A, Liu K Blood. 2016; 129(6):723-728.

PMID: 27856464 PMC: 5301825. DOI: 10.1182/blood-2016-07-727719.

References

Tordi N, Perrey S, Harvey A, Hughson R . Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans. J Appl Physiol (1985). 2002; 94(2):533-41. DOI: 10.1152/japplphysiol.00532.2002. View

Krustrup P, Gonzalez-Alonso J, Quistorff B, Bangsbo J . Muscle heat production and anaerobic energy turnover during repeated intense dynamic exercise in humans. J Physiol. 2001; 536(Pt 3):947-56. PMC: 2278909. DOI: 10.1111/j.1469-7793.2001.00947.x. View

Samb A, Kane M, Ba A, Gadji M, Seck D, Badji L . [Physical performance and thermoregulatory study of subjects with sickle cell trait during a sub-maximal exercise]. Dakar Med. 2005; 50(2):46-51. View

Bile A, Le Gallais D, Mercier B, Martinez P, Ahmaidi S, Prefaut C . Blood lactate concentrations during incremental exercise in subjects with sickle cell trait. Med Sci Sports Exerc. 1998; 30(5):649-54. DOI: 10.1097/00005768-199805000-00002. View

Martin T, Weisman I, Zeballos R, Stephenson S . Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. Am J Med. 1989; 87(1):48-56. DOI: 10.1016/s0002-9343(89)80482-6. View

Smith J, Telford R, Weidemann M . Lactate/H+ uptake by red blood cells during exercise alters their physical properties. Eur J Appl Physiol Occup Physiol. 1997; 75(1):54-61. DOI: 10.1007/s004210050126. View

Bishop D, Edge J, Goodman C . Muscle buffer capacity and aerobic fitness are associated with repeated-sprint ability in women. Eur J Appl Physiol. 2004; 92(4-5):540-7. DOI: 10.1007/s00421-004-1150-1. View

Perrey S, Candau R, Rouillon J, Hughson R . The effect of prolonged submaximal exercise on gas exchange kinetics and ventilation during heavy exercise in humans. Eur J Appl Physiol. 2003; 89(6):587-94. DOI: 10.1007/s00421-003-0822-6. View

Monchanin G, Connes P, Wouassi D, Francina A, Djoda B, Banga P . Hemorheology, sickle cell trait, and alpha-thalassemia in athletes: effects of exercise. Med Sci Sports Exerc. 2005; 37(7):1086-92. DOI: 10.1249/01.mss.0000170128.78432.96. View

10.

Stringer W, Wasserman K, Casaburi R, Porszasz J, Maehara K, French W . Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise. J Appl Physiol (1985). 1994; 76(4):1462-7. DOI: 10.1152/jappl.1994.76.4.1462. View

11.

Burnley M, Doust J, Carter H, Jones A . Effects of prior exercise and recovery duration on oxygen uptake kinetics during heavy exercise in humans. Exp Physiol. 2001; 86(3):417-25. DOI: 10.1113/eph8602122. View

12.

Le Gallais D, Prefaut C, Mercier J, Bile A, Bogui P, Lonsdorfer J . Sickle cell trait as a limiting factor for high-level performance in a semi-marathon. Int J Sports Med. 1994; 15(7):399-402. DOI: 10.1055/s-2007-1021077. View

13.

Ramirez A, HARTLEY L, Rhodes D, Abelmann W . Morphological features of red blood cells in subjects with sickle cell trait: changes during exercise. Arch Intern Med. 1976; 136(9):1064-6. DOI: 10.1001/archinte.1976.03630090086021. View

14.

Serjeant B, Mason K, Kenny M, Stuart J, Higgs D, Weatherall D . Effect of alpha thalassaemia on the rheology of homozygous sickle cell disease. Br J Haematol. 1983; 55(3):479-86. DOI: 10.1111/j.1365-2141.1983.tb02163.x. View

15.

Kark J, Ward F . Exercise and hemoglobin S. Semin Hematol. 1994; 31(3):181-225. View

16.

Wasserman K, McIlroy M . DETECTING THE THRESHOLD OF ANAEROBIC METABOLISM IN CARDIAC PATIENTS DURING EXERCISE. Am J Cardiol. 1964; 14:844-52. DOI: 10.1016/0002-9149(64)90012-8. View

17.

Robinson J, Stone W, Asendorf A . Exercise capacity of black sickle cell trait males. Med Sci Sports. 1976; 8(4):244-5. View

18.

Wasserman K, Whipp B, Koyl S, Beaver W . Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol. 1973; 35(2):236-43. DOI: 10.1152/jappl.1973.35.2.236. View

19.

Gerbino A, Ward S, Whipp B . Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J Appl Physiol (1985). 1996; 80(1):99-107. DOI: 10.1152/jappl.1996.80.1.99. View

20.

Connes P, Monchanin G, Perrey S, Wouassi D, Atchou G, Forsuh A . Oxygen uptake kinetics during heavy submaximal exercise: Effect of sickle cell trait with or without alpha-thalassemia. Int J Sports Med. 2006; 27(7):517-25. DOI: 10.1055/s-2005-865823. View