Oral Glucose Tolerance Test: a Reliable Tool for Early Detection of Glucose Abnormalities in Patients with Acute Myocardial Infarction in Clinical Practice: a Report on Repeated Oral Glucose Tolerance Tests from the GAMI Study

Objective: Previously undetected glucose abnormalities are common in patients with acute myocardial infarction (AMI). We evaluated long-term reliability of early glucometabolic classification of patients with AMI by repeated oral glucose tolerance tests (OGTTs).

Research Design And Methods: A glucometabolic OGTT-based classification was obtained in 122 patients by measuring capillary whole-blood glucose. The classification was performed on three occasions, before hospital discharge and 3 and 12 months thereafter.

Results: At discharge, 34, 31, and 34% were classified as having normal glucose tolerance, impaired glucose tolerance (IGT), or type 2 diabetes, respectively, and 93% of all patients with type 2 diabetes were still classified with type 2 diabetes (n = 27) or IGT (n = 12) after 12 months. The agreements between the OGTTs at discharge and 3 and 12 months were kappa = 0.35, P < 0.001, and kappa = 0.43, P < 0.001, respectively.

Conclusions: The outcome of an OGTT performed in AMI patients at hospital discharge reliably informs on long-term glucometabolic state.