A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9

Overview

Journal Cancer Res

Specialty Oncology

Date 2007 Oct 3

PMID 17908996

Citations 72

Authors

Geraldine M ONeill

Sachiko Seo

Ilya G Serebriiskii

Stuart R Lessin

Erica A Golemis

Affiliations

Soon will be listed here.

Abstract

Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.

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