Food Reinforcement, the Dopamine D2 Receptor Genotype, and Energy Intake in Obese and Nonobese Humans

Overview

Journal Behav Neurosci

Publisher American Psychological Association

Specialty Psychology

Date 2007 Oct 3

PMID 17907820

Citations 152

Authors

Leonard H Epstein

Jennifer L Temple

Brad J Neaderhiser

Robbert J Salis

Richard W Erbe

John J Leddy

Affiliations

Soon will be listed here.

Abstract

The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.

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References

Saelens B, Epstein L . Reinforcing value of food in obese and non-obese women. Appetite. 1996; 27(1):41-50. DOI: 10.1006/appe.1996.0032. View

Goldfield G, Epstein L, Davidson M, Saad F . Validation of a questionnaire measure of the relative reinforcing value of food. Eat Behav. 2005; 6(3):283-92. DOI: 10.1016/j.eatbeh.2004.11.004. View

Grandy D, Litt M, Allen L, Bunzow J, Marchionni M, Makam H . The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. Am J Hum Genet. 1989; 45(5):778-85. PMC: 1683432. View

Hsiao S, Smith G . Raclopride reduces sucrose preference in rats. Pharmacol Biochem Behav. 1995; 50(1):121-5. DOI: 10.1016/0091-3057(95)00315-n. View

Whitaker R, Wright J, Pepe M, Seidel K, Dietz W . Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997; 337(13):869-73. DOI: 10.1056/NEJM199709253371301. View

Carr K . Feeding, drug abuse, and the sensitization of reward by metabolic need. Neurochem Res. 1996; 21(11):1455-67. DOI: 10.1007/BF02532386. View

Vandenbergh D, Persico A, Hawkins A, Griffin C, Li X, Jabs E . Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 1992; 14(4):1104-6. DOI: 10.1016/s0888-7543(05)80138-7. View

Epstein L, Wright S, Paluch R, Leddy J, Hawk Jr L, Jaroni J . Food hedonics and reinforcement as determinants of laboratory food intake in smokers. Physiol Behav. 2004; 81(3):511-7. DOI: 10.1016/j.physbeh.2004.02.015. View

Pohjalainen T, Rinne J, Nagren K, Lehikoinen P, Anttila K, Syvalahti E . The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry. 1998; 3(3):256-60. DOI: 10.1038/sj.mp.4000350. View

10.

Bahk J, Li S, Park M, Kim M . Dopamine D1 and D2 receptor mRNA up-regulation in the caudate-putamen and nucleus accumbens of rat brains by smoking. Prog Neuropsychopharmacol Biol Psychiatry. 2002; 26(6):1095-104. DOI: 10.1016/s0278-5846(02)00243-9. View

11.

Klesges R, Meyers A, Klesges L, La Vasque M . Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature. Psychol Bull. 1989; 106(2):204-30. DOI: 10.1037/0033-2909.106.2.204. View

12.

Epstein L, Wright S, Paluch R, Leddy J, Hawk Jr L, Jaroni J . Relation between food reinforcement and dopamine genotypes and its effect on food intake in smokers. Am J Clin Nutr. 2004; 80(1):82-8. DOI: 10.1093/ajcn/80.1.82. View

13.

Stunkard A, Messick S . The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res. 1985; 29(1):71-83. DOI: 10.1016/0022-3999(85)90010-8. View

14.

Cooper P, Taylor C, Lask B . The use of the eating disorder examination with children: a pilot study. Int J Eat Disord. 1996; 19(4):391-7. DOI: 10.1002/(SICI)1098-108X(199605)19:4<391::AID-EAT6>3.0.CO;2-G. View

15.

Temple J, Giacomelli A, Roemmich J, Epstein L . Dietary variety impairs habituation in children. Health Psychol. 2008; 27(1S):S10-9. PMC: 2291292. DOI: 10.1037/0278-6133.27.1.S10. View

16.

Epstein L, Dearing K, Temple J, Cavanaugh M . Food reinforcement and impulsivity in overweight children and their parents. Eat Behav. 2008; 9(3):319-27. PMC: 4682358. DOI: 10.1016/j.eatbeh.2007.10.007. View

17.

Ritchie T, Noble E . Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res. 2003; 28(1):73-82. DOI: 10.1023/a:1021648128758. View

18.

Janson A, Hedlund P, Fuxe K, von Euler G . Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat. Brain Res. 1994; 655(1-2):25-32. DOI: 10.1016/0006-8993(94)91593-8. View

19.

Neville M, Johnstone E, Walton R . Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat. 2004; 23(6):540-5. DOI: 10.1002/humu.20039. View

20.

Jonsson E, Nothen M, Grunhage F, Farde L, Nakashima Y, Propping P . Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry. 1999; 4(3):290-6. DOI: 10.1038/sj.mp.4000532. View