Neural Cell Adhesion Molecule-180 Expression As a Prognostic Criterion in Colorectal Carcinoma: Feasible or Not?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Oct 2

PMID 17907291

Citations 2

Authors

Oge Tascilar

Guldeniz Karadeniz Cakmak

Ishak Ozel Tekin

Ali-Ugur Emre

Bulent Hamdi Ucan

Oktay Irkorucu

Kemal Karakaya

Mesut Gul

Huseyin Bulent Engin

Mustafa Comert

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.

Methods: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.

Results: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up.

Conclusion: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

Citing Articles

Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions.

Sowparani S, Mahalakshmi P, Sweety J, Francis A, Dhanalekshmi U, Selvasudha N Mol Neurobiol. 2022; 59(9):5902-5924.

PMID: 35831555 DOI: 10.1007/s12035-022-02954-9.

Expression Level of Genes Coding for Cell Adhesion Molecules of Cadherin Group in Colorectal Cancer Patients.

Lorenc Z, Opilka M, Kruszniewska-Rajs C, Rajs A, Waniczek D, Starzewska M Med Sci Monit. 2015; 21:2031-40.

PMID: 26167814 PMC: 4514365. DOI: 10.12659/MSM.893610.

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