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Neural Cell Adhesion Molecule-180 Expression As a Prognostic Criterion in Colorectal Carcinoma: Feasible or Not?

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Specialty Gastroenterology
Date 2007 Oct 2
PMID 17907291
Citations 2
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Abstract

Aim: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.

Methods: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.

Results: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up.

Conclusion: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

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Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions.

Sowparani S, Mahalakshmi P, Sweety J, Francis A, Dhanalekshmi U, Selvasudha N Mol Neurobiol. 2022; 59(9):5902-5924.

PMID: 35831555 DOI: 10.1007/s12035-022-02954-9.


Expression Level of Genes Coding for Cell Adhesion Molecules of Cadherin Group in Colorectal Cancer Patients.

Lorenc Z, Opilka M, Kruszniewska-Rajs C, Rajs A, Waniczek D, Starzewska M Med Sci Monit. 2015; 21:2031-40.

PMID: 26167814 PMC: 4514365. DOI: 10.12659/MSM.893610.

References
1.
Vural E, Hutcheson J, Korourian S, Kechelava S, Hanna E . Correlation of neural cell adhesion molecules with perineural spread of squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 2000; 122(5):717-20. DOI: 10.1016/S0194-5998(00)70203-8. View

2.
Huerta S, Srivatsan E, Venkatesan N, Peters J, Moatamed F, Renner S . Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule. Surgery. 2001; 130(5):834-43. DOI: 10.1067/msy.2001.116415. View

3.
Rutishauser U, Acheson A, Hall A, Mann D, Sunshine J . The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science. 1988; 240(4848):53-7. DOI: 10.1126/science.3281256. View

4.
Hildebrandt H, Becker C, Gluer S, Rosner H, Gerardy-Schahn R, Rahmann H . Polysialic acid on the neural cell adhesion molecule correlates with expression of polysialyltransferases and promotes neuroblastoma cell growth. Cancer Res. 1998; 58(4):779-84. View

5.
Goridis C, Brunet J . NCAM: structural diversity, function and regulation of expression. Semin Cell Biol. 1992; 3(3):189-97. DOI: 10.1016/s1043-4682(10)80015-7. View