The Thrombotic Microangiopathies

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2007 Oct 2

PMID 17906963

Citations 21

Authors

Lawrence Copelovitch

Bernard S Kaplan

Affiliations

Soon will be listed here.

Abstract

The term thrombotic microangiopathy (TMA) encompasses a group of conditions that are defined by, or result from, a similar histopathological lesion. Hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and several other conditions are associated with TMA. Distinguishing HUS from TTP is not always possible unless there are specific causes, such as Shiga toxin, Streptococcus pneumoniae, or a specific molecular defect such as factor H or ADAMTS13 deficiency. This review describes the forms of HUS/TTP that are not related to Shiga toxin, pneumococcal infection, genetic causes, or ADAMTS13 deficiency. Conditions include HUS/TTP associated with autoimmune disorders, human immunodeficiency virus (HIV) infection, transplantation, malignancy, and medications.

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