Beta Adrenergic Receptors in Keratinocytes

Overview

Journal Dermatol Clin

Specialty Dermatology

Date 2007 Oct 2

PMID 17903623

Citations 30

Authors

Raja K Sivamani

Susanne T Lam

R Rivkah Isseroff

Affiliations

Soon will be listed here.

Abstract

Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in their expression, signaling pathway, or in the generation of endogenous catecholamine agonists by keratinocytes have been implicated in the pathogenesis of cutaneous diseases such as atopic dermatitis, vitiligo, and psoriasis. New studies also indicate that the beta2AR also modulates keratinocyte migration, and thus can function to regulate wound reepithelialization. This review focuses on the function of these receptors in keratinocytes and their contribution to cutaneous physiology and disease.

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