Morphological and Functional Imaging in COPD with CT and MRI: Present and Future

Overview

Journal Eur Radiol

Specialty Radiology

Date 2007 Sep 28

PMID 17899100

Citations 27

Authors

Julia Ley-Zaporozhan

Sebastian Ley

Hans-Ulrich Kauczor

Affiliations

Soon will be listed here.

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway collapse), the parenchyma (i.e. hyperinflation, air trapping and emphysematous destruction) as well as the vasculature (i.e. hypoxic vasoconstriction, rarefication and pulmonary arterial hypertension) with different severity during the course of the disease. These different aspects of COPD can be best addressed by imaging using a combination of morphological and functional techniques. Three-dimensional high-resolution computed tomography (3D-HRCT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about perfusion, regional lung mechanics, and ventilation mainly provided by MRI. The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization and dedicated therapy monitoring of COPD as presented in this review.

Citing Articles

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References

Kinsella M, Muller N, Abboud R, Morrison N, Dybuncio A . Quantitation of emphysema by computed tomography using a "density mask" program and correlation with pulmonary function tests. Chest. 1990; 97(2):315-21. DOI: 10.1378/chest.97.2.315. View

Bankier A, Madani A, Gevenois P . CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 2003; 43(6):399-417. View

Budev M, Arroliga A, Wiedemann H, Matthay R . Cor pulmonale: an overview. Semin Respir Crit Care Med. 2005; 24(3):233-44. DOI: 10.1055/s-2003-41105. View

Hoffman E, Simon B, McLennan G . State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006; 3(6):519-32. PMC: 2647643. DOI: 10.1513/pats.200603-086MS. View

Biederer J, Both M, Graessner J, Liess C, Jakob P, Reuter M . Lung morphology: fast MR imaging assessment with a volumetric interpolated breath-hold technique: initial experience with patients. Radiology. 2003; 226(1):242-9. DOI: 10.1148/radiol.2261011974. View

Ley-Zaporozhan J, Ley S, Kauczor H . Proton MRI in COPD. COPD. 2007; 4(1):55-65. DOI: 10.1080/15412550701198719. View

Stoel B, Stolk J . Optimization and standardization of lung densitometry in the assessment of pulmonary emphysema. Invest Radiol. 2004; 39(11):681-8. DOI: 10.1097/00004424-200411000-00006. View

Sandek K, Bratel T, Lagerstrand L, Rosell H . Relationship between lung function, ventilation-perfusion inequality and extent of emphysema as assessed by high-resolution computed tomography. Respir Med. 2002; 96(11):934-43. DOI: 10.1053/rmed.2002.1371. View

Zaporozhan J, Ley S, Weinheimer O, Eberhardt R, Tsakiris I, Noshi Y . Multi-detector CT of the chest: influence of dose onto quantitative evaluation of severe emphysema: a simulation study. J Comput Assist Tomogr. 2006; 30(3):460-8. DOI: 10.1097/00004728-200605000-00018. View

10.

Beckmann N, Cannet C, Zurbruegg S, Rudin M, Tigani B . Proton MRI of lung parenchyma reflects allergen-induced airway remodeling and endotoxin-aroused hyporesponsiveness: a step toward ventilation studies in spontaneously breathing rats. Magn Reson Med. 2004; 52(2):258-68. DOI: 10.1002/mrm.20127. View

11.

Guenther D, Eberle B, Hast J, Lill J, Markstaller K, Puderbach M . (3)He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes. NMR Biomed. 2000; 13(4):182-9. DOI: 10.1002/1099-1492(200006)13:4<182::aid-nbm642>3.0.co;2-n. View

12.

Ohno Y, Sugimura K, Hatabu H . Clinical oxygen-enhanced magnetic resonance imaging of the lung. Top Magn Reson Imaging. 2003; 14(3):237-43. DOI: 10.1097/00002142-200306000-00004. View

13.

Fink C, Puderbach M, Bock M, Lodemann K, Zuna I, Schmahl A . Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology. 2004; 231(1):175-84. DOI: 10.1148/radiol.2311030193. View

14.

Hasegawa M, Nasuhara Y, Onodera Y, Makita H, Nagai K, Fuke S . Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006; 173(12):1309-15. DOI: 10.1164/rccm.200601-037OC. View

15.

Swift A, Wild J, Fichele S, Woodhouse N, Fleming S, Waterhouse J . Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI. Eur J Radiol. 2005; 54(3):352-8. DOI: 10.1016/j.ejrad.2004.08.002. View

16.

Iwasawa T, Yoshiike Y, Saito K, Kagei S, Gotoh T, Matsubara S . Paradoxical motion of the hemidiaphragm in patients with emphysema. J Thorac Imaging. 2000; 15(3):191-5. DOI: 10.1097/00005382-200007000-00007. View

17.

Gevenois P, De Maertelaer V, De Vuyst P, ZANEN J, Yernault J . Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med. 1995; 152(2):653-7. DOI: 10.1164/ajrccm.152.2.7633722. View

18.

Suga K, Tsukuda T, Awaya H, Takano K, Koike S, Matsunaga N . Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. J Magn Reson Imaging. 1999; 10(4):510-20. DOI: 10.1002/(sici)1522-2586(199910)10:4<510::aid-jmri3>3.0.co;2-g. View

19.

Aziz Z, Wells A, Desai S, Ellis S, Walker A, MacDonald S . Functional impairment in emphysema: contribution of airway abnormalities and distribution of parenchymal disease. AJR Am J Roentgenol. 2005; 185(6):1509-15. DOI: 10.2214/AJR.04.1578. View

20.

Kauczor H . Hyperpolarized helium-3 gas magnetic resonance imaging of the lung. Top Magn Reson Imaging. 2003; 14(3):223-30. DOI: 10.1097/00002142-200306000-00002. View