Nitric Oxide Pathways and Evidence-based Perturbations in Acute Pancreatitis

Overview

Journal Pancreatology

Specialties Endocrinology
Gastroenterology

Date 2007 Sep 28

PMID 17898529

Citations 6

Authors

Matthew J DiMagno

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) is a gaseous neurotransmitter, a vasodilator and paracrine regulator. In the pancreas, NO regulates normal pancreatic exocrine secretion, endocrine pancreatic insulin secretion and pancreatic microvascular blood flow. NO has multiple species and is produced de novo by 3 NO synthase enzymes. Endothelial NO synthase reduces the severity of the initial phase of experimental acute pancreatitis (AP). Cigarette smoking and chronic alcohol use disrupt normal NO pathways and are associated with pancreatitis and pancreatic cancer. The aims of this minireview are to describe normal intrapancreatic NO pathways, perturbations during experimental AP and due to epidemiological factors associated with pancreatic pathology, and the clinical implications of NO on AP.

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