Preoperative FMRI Predicts Memory Decline Following Anterior Temporal Lobe Resection

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 2007 Sep 28

PMID 17898035

Citations 38

Authors

H W R Powell

M P Richardson

M R Symms

P A Boulby

P J Thompson

J S Duncan

M J Koepp

Affiliations

Soon will be listed here.

Abstract

Background: Anterior temporal lobe resection (ATLR) benefits many patients with refractory temporal lobe epilepsy (TLE) but may be complicated by material specific memory impairments, typically of verbal memory following left ATLR, and non-verbal memory following right ATLR. Preoperative memory functional MRI (fMRI) may help in the prediction of these deficits.

Objective: To assess the value of preoperative fMRI in the prediction of material specific memory deficits following both left- and right-sided ATLR.

Methods: We report 15 patients with unilateral TLE undergoing ATLR; eight underwent dominant hemisphere ATLR and seven non-dominant ATLR. Patients performed an fMRI memory paradigm which examined the encoding of words, pictures and faces.

Results: Individual patients with relatively greater ipsilateral compared with contralateral medial temporal lobe activation had greater memory decline following ATLR. This was the case for both verbal memory decline following dominant ATLR and for non-verbal memory decline following non-dominant ATLR. For verbal memory decline, activation within the dominant hippocampus was predictive of postoperative memory change whereas activation in the non-dominant hippocampus was not.

Conclusion: These findings suggest that preoperative memory fMRI may be a useful non-invasive predictor of postoperative memory change following ATLR and provide support for the functional adequacy theory of hippocampal function. They also suggest that fMRI may provide additional information, over that provided by neuropsychology, for use in the prediction of postoperative memory decline.

Citing Articles

Test-retest reliability of the "Home Town Walk" fMRI paradigm for memory activation and lateralization in the pre-surgical evaluation of patients with temporal lobe epilepsy.

Sanchez Panchuelo R, Flintham R, Wesolowski R, Jalali R, Herbert J, Samarasekera S Front Neurol. 2024; 15:1419047.

PMID: 39108656 PMC: 11300360. DOI: 10.3389/fneur.2024.1419047.

Task-based functional magnetic resonance imaging prediction of postsurgical cognitive outcomes in temporal lobe epilepsy: A systematic review, meta-analysis, and new data.

Crow A, Thomas A, Rao Y, Beloor-Suresh A, Weinstein D, Hinds W Epilepsia. 2022; 64(2):266-283.

PMID: 36522799 PMC: 9944224. DOI: 10.1111/epi.17475.

Sonoda M, Rothermel R, Carlson A, Jeong J, Lee M, Hayashi T Brain. 2022; 145(2):517-530.

PMID: 35313351 PMC: 9014727. DOI: 10.1093/brain/awab318.

A Guide to Designing a Memory fMRI Paradigm for Pre-surgical Evaluation in Temporal Lobe Epilepsy.

Buck S, Sidhu M Front Neurol. 2020; 10:1354.

PMID: 31998216 PMC: 6962296. DOI: 10.3389/fneur.2019.01354.

Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy.

Massot-Tarrus A, White K, Mirsattari S Curr Neurol Neurosci Rep. 2019; 19(6):31.

PMID: 31044310 DOI: 10.1007/s11910-019-0945-8.

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