BDNF Val66Met Variant and Age of Onset in Schizophrenia

Overview

Journal Am J Med Genet B Neuropsychiatr Genet

Specialties Genetics
Neurology
Psychiatry

Date 2007 Sep 27

PMID 17894414

Citations 17

Authors

Helen M Chao

Hung-Teh Kao

Barbara Porton

Affiliations

Soon will be listed here.

Abstract

Brain-derived neurotrophic factor (BDNF) has been advanced as a candidate gene for schizophrenia by virtue of its effects on neurotransmitter systems that are dysregulated in psychiatric disorder and its involvement in the response to antipsychotic drugs. The extensively examined BDNF gene Val66Met (or rs6265) variant has been associated with schizophrenia, and studies have linked this polymorphism to brain morphology, cognitive function, and psychiatric symptoms in schizophrenia. Moreover the BDNF Val66Met variant has been reported to be associated with age of onset in schizophrenia. Genotyping of African-American subjects with schizophrenia for five BDNF coding region single nucleotide polymorphisms revealed variance only at the Val66Met allele. The results of statistical analyses indicate a relationship between the BDNF Val66Met genotype and the ages of first psychiatric hospitalization and first schizophrenia symptoms.

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References

Egan M, Kojima M, Callicott J, Goldberg T, Kolachana B, Bertolino A . The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003; 112(2):257-69. DOI: 10.1016/s0092-8674(03)00035-7. View

Chen Z, Patel P, Sant G, Meng C, Teng K, Hempstead B . Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci. 2004; 24(18):4401-11. PMC: 6729450. DOI: 10.1523/JNEUROSCI.0348-04.2004. View

Cloninger C, Kaufmann C, Faraone S, Malaspina D, Svrakic D, Harkavy-Friedman J . Genome-wide search for schizophrenia susceptibility loci: the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet. 1998; 81(4):275-81. View

Strauss J, Barr C, George C, King N, Shaikh S, Devlin B . Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder. Am J Med Genet B Neuropsychiatr Genet. 2004; 131B(1):16-9. DOI: 10.1002/ajmg.b.30041. View

Angelucci F, Brene S, Mathe A . BDNF in schizophrenia, depression and corresponding animal models. Mol Psychiatry. 2005; 10(4):345-52. DOI: 10.1038/sj.mp.4001637. View

Kanazawa T, Glatt S, Kia-Keating B, Yoneda H, Tsuang M . Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Psychiatr Genet. 2007; 17(3):165-70. DOI: 10.1097/YPG.0b013e32801da2e2. View

Szeszko P, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S . Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry. 2005; 10(7):631-6. DOI: 10.1038/sj.mp.4001656. View

Gourion D, Goldberger C, Leroy S, Bourdel M, Olie J, Krebs M . Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants. Neuroreport. 2005; 16(12):1407-10. DOI: 10.1097/01.wnr.0000175245.58708.6b. View

Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Ohta K . Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett. 2006; 401(1-2):1-5. DOI: 10.1016/j.neulet.2006.02.054. View

10.

Naoe Y, Shinkai T, Hori H, Fukunaka Y, Utsunomiya K, Sakata S . No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis. Neurosci Lett. 2007; 415(2):108-12. DOI: 10.1016/j.neulet.2007.01.006. View

11.

Gratacos M, Gonzalez J, Mercader J, de Cid R, Urretavizcaya M, Estivill X . Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry. 2007; 61(7):911-22. DOI: 10.1016/j.biopsych.2006.08.025. View

12.

Shoval G, Weizman A . The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur Neuropsychopharmacol. 2005; 15(3):319-29. DOI: 10.1016/j.euroneuro.2004.12.005. View