The Characteristics of Relapse in Adult-onset Minimal-change Nephrotic Syndrome

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2007 Sep 25

PMID 17891348

Citations 16

Authors

Takashi Takei

Minako Koike

Koichi Suzuki

Satsuki Shirota

Mitsuyo Itabashi

Shigeru Ohtsubo

Hidekazu Sugiura

Keiko Suzuki

Chiari Kojima

Masaki Takahashi

Jun Ino

Tetsuya Ogawa

Keiko Uchida

Ken Tsuchiya

Wako Yumura

Kosaku Nitta

Affiliations

Soon will be listed here.

Abstract

Background: Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk.

Methods: To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico-pathophysiological characteristics between the two groups.

Results: Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group.

Conclusions: To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.

Citing Articles

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Liu L, Zhang W, Huang M, Li K, Zhu L, Ke L Front Med (Lausanne). 2024; 11:1352206.

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A case of minimal change nephrotic syndrome complicated by Kimura disease treated with rituximab.

Yoshida R, Hara Y, Fujii Y, Matuda H CEN Case Rep. 2023; 12(4):368-373.

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Development and validation of a simple-to-use nomogram for predicting minimal change disease based on quantification of color Doppler sonography data from a region of interest.

Ma L, Zhang Y, Zhang L, Shao C, Yu N Abdom Radiol (NY). 2023; 48(3):1020-1032.

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Spontaneous remission of minimal change nephrotic syndrome in an elderly man.

Chiba Y, Nagasawa T, Kin S, Takahashi K, Yoshida M, Oe Y CEN Case Rep. 2021; 10(2):301-307.

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Establishment of a novel nomogram for the clinically diagnostic prediction of minimal change disease, -a common cause of nephrotic syndrome.

Yan G, Liu G, Tian X, Tian L, Wang H, Ren P BMC Nephrol. 2020; 21(1):396.

PMID: 32928127 PMC: 7490860. DOI: 10.1186/s12882-020-02058-3.

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