Noninvasive Assessment of the Effects of Glucagon on the Gastric Slow Wave

Overview

Journal Am J Physiol Gastrointest Liver Physiol

Publisher American Physiological Society

Specialties Gastroenterology
Physiology

Date 2007 Sep 22

PMID 17884978

Citations 12

Authors

L Alan Bradshaw

Jared A Sims

William O Richards

Affiliations

Soon will be listed here.

Abstract

Hyperglycemic effects on the gastric slow wave are not well understood, and no studies have examined the effects that hyperglycemia has on gastric slow wave magnetic fields. We recorded multichannel magnetogastrograms (MGGs) before and after intravenous administration of glucagon and subsequent modest hyperglycemia in 20 normal volunteers. Normal slow waves were evident in baseline MGG recordings from all 20 subjects, but within 15 min after glucagon had been given, we noted significant effects on MGG signals. In addition to an overall decrease in the slow wave frequency from 2.9 +/- 0.5 cycles per min (cpm) to 2.2 +/- 0.1 cpm (P < 0.05), we observed significant changes in the number and range of spectral peaks recorded. Furthermore, the propagation velocity determined from surface current density maps computed from the multichannel MGG decreased significantly (7.1 +/- 0.8 mm/s to 5.0 +/- 0.3 mm/s, P < 0.05). This is the first study of biomagnetic effects of hyperglycemia in normal subjects. Our results suggest that the analysis of the MGG provides parameter quantification for gastric electrical activity specific to and characteristic of slow wave abnormalities associated with increased serum glucose by injection of glucagon.

Citing Articles

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Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.

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Simultaneous anterior and posterior serosal mapping of gastric slow-wave dysrhythmias induced by vasopressin.

Du P, OGrady G, Paskaranandavadivel N, Tang S, Abell T, Cheng L Exp Physiol. 2016; 101(9):1206-1217.

PMID: 27265885 PMC: 5140776. DOI: 10.1113/EP085697.

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