Organic Anion Transporting Polypeptide-1B1 Haplotypes in Chinese Patients

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2007 Sep 22

PMID 17883959

Citations 20

Authors

Lin-Yong Xu

Yi-Jing He

Wei Zhang

Sheng Deng

Qing Li

Wei-Xia Zhang

Zhao-Qian Liu

Dan Wang

Yuan-Fei Huang

Hong-Hao Zhou

Zhen-qiu Sun

Affiliations

Soon will be listed here.

Abstract

Aim: To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.

Methods: One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.

Results: The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.

Conclusion: The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.

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