Age-stratified Prevalences of Pneumococcal-serotype-specific Immunoglobulin G in England and Their Relationship to the Serotype-specific Incidence of Invasive Pneumococcal Disease Prior to the Introduction of the Pneumococcal 7-valent Conjugate...

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2007 Sep 21

PMID 17881503

Citations 17

Authors

Paul Balmer

Ray Borrow

Jamie Findlow

Rosalind Warrington

Sarah Frankland

Pauline Waight

Robert George

Nick Andrews

Elizabeth Miller

Affiliations

Soon will be listed here.

Abstract

Recent changes to the childhood immunization schedule in the United Kingdom have resulted in the inclusion of the 7-valent pneumococcal conjugate vaccine. However, the seroprevalence of pneumococcal antibodies in the population was unknown. To address this, we measured pneumococcal, age-specific immunoglobulin G (IgG) concentrations specific for nine serotypes by an assay run on the Bioplex platform, using 2,664 serum samples collected in England from 2000 to 2004. The lowest concentrations of IgG specific to all serotypes and the proportions of serotype-specific IgG concentrations of >/=0.35 microg/ml were observed in children aged <1 year. From 1 year on, there was a general increase in antibody levels with increasing age, and they remained high in adults. Maternal antibody was detected in young children aged <36 days but waned rapidly. Comparison of the age-specific seroprevalence of serotype-specific IgG to the serotype-specific incidence of invasive pneumococcal disease demonstrated a general inverse relationship for all age groups except the elderly. These data provide a baseline for natural immunity to the pneumococcal serotypes analyzed prior to the introduction of pneumococcal conjugate vaccine in the United Kingdom.

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