The Significance of 3-O-methyldopa Concentrations in the Cerebrospinal Fluid in the Pathogenesis of Wearing-off Phenomenon in Parkinson's Disease

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1991 Oct 28

PMID 1787913

Citations 13

Authors

H Tohgi

T Abe

T Kikuchi

S Takahashi

Y Nozaki

Affiliations

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Abstract

We determined concentrations of 3-O-methyldopa (3-OMD), L-3,4-dihydroxyphenylalanine (L-dopa), dopamine (DA) and other related substances in the cerebrospinal fluid in patients with Parkinson's disease (PD) 15 h after L-dopa/carbidopa medication, and compared patients with and without the wearing-off phenomenon. Concentrations of 3-OMD significantly increased, and the ratio of DA to 3-OMD was significantly shifted in favor of 3-OMD in patients with the wearing-off compared with patients without the wearing-off. However, concentrations of L-dopa, DA, and homovanillic acid (HVA) were not different between the groups. These results suggest that even if 3-OMD is related to the pathogenesis of the wearing-off, it is not through competition with L-dopa for uptake into the brain, but through other unknown mechanisms within the brain.

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