Psilocybin Links Binocular Rivalry Switch Rate to Attention and Subjective Arousal Levels in Humans

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2007 Sep 18

PMID 17874073

Citations 58

Authors

Olivia L Carter

Felix Hasler

John D Pettigrew

Guy M Wallis

Guang B Liu

Franz X Vollenweider

Affiliations

Soon will be listed here.

Abstract

Rationale: Binocular rivalry occurs when different images are simultaneously presented to each eye. During continual viewing of this stimulus, the observer will experience repeated switches between visual awareness of the two images. Previous studies have suggested that a slow rate of perceptual switching may be associated with clinical and drug-induced psychosis.

Objectives: The objective of the study was to explore the proposed relationship between binocular rivalry switch rate and subjective changes in psychological state associated with 5-HT2A receptor activation.

Materials And Methods: This study used psilocybin, the hallucinogen found naturally in Psilocybe mushrooms that had previously been found to induce psychosis-like symptoms via the 5-HT2A receptor. The effects of psilocybin (215 microg/kg) were considered alone and after pretreatment with the selective 5-HT2A antagonist ketanserin (50 mg) in ten healthy human subjects.

Results: Psilocybin significantly reduced the rate of binocular rivalry switching and increased the proportion of transitional/mixed percept experience. Pretreatment with ketanserin blocked the majority of psilocybin's "positive" psychosis-like hallucinogenic symptoms. However, ketanserin had no influence on either the psilocybin-induced slowing of binocular rivalry or the drug's "negative-type symptoms" associated with reduced arousal and vigilance.

Conclusions: Together, these findings link changes in binocular rivalry switching rate to subjective levels of arousal and attention. In addition, it suggests that psilocybin's effect on binocular rivalry is unlikely to be mediated by the 5-HT2A receptor.

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References

Krebs-Thomson K, Ruiz E, Masten V, Buell M, Geyer M . The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats. Psychopharmacology (Berl). 2006; 189(3):319-29. DOI: 10.1007/s00213-006-0566-1. View

Paffen C, Alais D, Verstraten F . Attention speeds binocular rivalry. Psychol Sci. 2006; 17(9):752-6. DOI: 10.1111/j.1467-9280.2006.01777.x. View

Wong D, Lever J, Hartig P, Dannals R, Villemagne V, HOFFMAN B . Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-Br-LSD. Synapse. 1987; 1(5):393-8. DOI: 10.1002/syn.890010502. View

Wittmann M, Carter O, Hasler F, Cahn B, Grimberg U, Spring P . Effects of psilocybin on time perception and temporal control of behaviour in humans. J Psychopharmacol. 2006; 21(1):50-64. DOI: 10.1177/0269881106065859. View

Aghajanian G, Hailgler H . Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors. Psychopharmacol Commun. 1975; 1(6):619-29. View

Vollenweider F, Csomor P, Knappe B, Geyer M, Quednow B . The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology. 2007; 32(9):1876-87. DOI: 10.1038/sj.npp.1301324. View

Lambe E, Aghajanian G . Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation. Neuroscience. 2007; 145(3):900-10. PMC: 1894690. DOI: 10.1016/j.neuroscience.2006.12.048. View

Foote S, Bloom F, Aston-Jones G . Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev. 1983; 63(3):844-914. DOI: 10.1152/physrev.1983.63.3.844. View

Carter O, Presti D, Callistemon C, Ungerer Y, Liu G, Pettigrew J . Meditation alters perceptual rivalry in Tibetan Buddhist monks. Curr Biol. 2005; 15(11):R412-3. DOI: 10.1016/j.cub.2005.05.043. View

10.

Brainard D . The Psychophysics Toolbox. Spat Vis. 1997; 10(4):433-6. View

11.

Jakab R, Goldman-Rakic P . 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci U S A. 1998; 95(2):735-40. PMC: 18490. DOI: 10.1073/pnas.95.2.735. View

12.

Cimmer C, Szendi I, Csifcsak G, Szekeres G, Kovacs Z, Somogyi I . Abnormal neurological signs, visual contrast sensitivity, and the deficit syndrome of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2006; 30(7):1225-30. DOI: 10.1016/j.pnpbp.2006.03.021. View

13.

Wilson H, Blake R, Lee S . Dynamics of travelling waves in visual perception. Nature. 2001; 412(6850):907-10. DOI: 10.1038/35091066. View

14.

Umbricht D, Vollenweider F, Schmid L, Grubel C, Skrabo A, Huber T . Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia. Neuropsychopharmacology. 2002; 28(1):170-81. DOI: 10.1038/sj.npp.1300005. View

15.

Sheinberg D, Logothetis N . The role of temporal cortical areas in perceptual organization. Proc Natl Acad Sci U S A. 1997; 94(7):3408-13. PMC: 20383. DOI: 10.1073/pnas.94.7.3408. View

16.

Dittrich A . The standardized psychometric assessment of altered states of consciousness (ASCs) in humans. Pharmacopsychiatry. 1998; 31 Suppl 2:80-4. DOI: 10.1055/s-2007-979351. View

17.

Gonzalez-Maeso J, Weisstaub N, Zhou M, Chan P, Ivic L, Ang R . Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007; 53(3):439-52. DOI: 10.1016/j.neuron.2007.01.008. View

18.

Hamon M, Gozlan H, El Mestikawy S, Emerit M, Bolanos F, Schechter L . The central 5-HT1A receptors: pharmacological, biochemical, functional, and regulatory properties. Ann N Y Acad Sci. 1990; 600:114-29; discussion 129-31. DOI: 10.1111/j.1749-6632.1990.tb16877.x. View

19.

Beique J, Imad M, Mladenovic L, Gingrich J, Andrade R . Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proc Natl Acad Sci U S A. 2007; 104(23):9870-5. PMC: 1887564. DOI: 10.1073/pnas.0700436104. View

20.

Tong F, Engel S . Interocular rivalry revealed in the human cortical blind-spot representation. Nature. 2001; 411(6834):195-9. DOI: 10.1038/35075583. View