Mechanisms of Eosinophilia in the Pathogenesis of Hypereosinophilic Disorders

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2007 Sep 18

PMID 17868854

Citations 52

Authors

Steven J Ackerman

Bruce S Bochner

Affiliations

Soon will be listed here.

Abstract

The increased numbers of activated eosinophils in the blood and tissues that typically accompany hypereosinophilic disorders result from a variety of mechanisms. Exciting advances in translating discoveries achieved from mouse models and molecular strategies to the clinic have led to a flurry of new therapeutics specifically designed to target eosinophil-associated diseases. So far, this form of hypothesis testing in humans in vivo through pharmacology generally has supported the paradigms generated in vitro and in animal models, raising hopes that a spectrum of novel therapies soon may become available to help those who have eosinophil-associated diseases.

Citing Articles

Severe conjunctival allergic reaction to polyglactin 910 sutures following strabismus surgery: A case report.

AlOtaibi K, Babgi R, Sesma G Int J Surg Case Rep. 2024; 122:110168.

PMID: 39146665 PMC: 11379584. DOI: 10.1016/j.ijscr.2024.110168.

Successful treatment of eosinophilia associated with dialysis-related renal cancer with radical nephrectomy.

Goto Y, Tamura D, Matsuura T, Shiomi E, Ikarashi D, Maekawa S IJU Case Rep. 2024; 7(4):301-304.

PMID: 38966767 PMC: 11221936. DOI: 10.1002/iju5.12729.

An Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review.

Cieza-Terrones M, De La Flor J, Requejo C, Villa D, Apaza J, Rodriguez-Doyaguez P Medicines (Basel). 2024; 11(6).

PMID: 38921600 PMC: 11206110. DOI: 10.3390/medicines11060013.

Clinical and Therapeutic Intervention of Hypereosinophilia in the Era of Molecular Diagnosis.

Nguyen L, Saha A, Kuykendall A, Zhang L Cancers (Basel). 2024; 16(7).

PMID: 38611061 PMC: 11011008. DOI: 10.3390/cancers16071383.

Critical deterioration of chronic eosinophilic pneumonia during pregnancy.

Vernon-Elliot J, Prasad J, Bonney A BMJ Case Rep. 2024; 17(2).

PMID: 38395471 PMC: 10895239. DOI: 10.1136/bcr-2023-259019.

References

Yamanaka R, Barlow C, Castilla L, Liu P, Eckhaus M, Decker T . Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc Natl Acad Sci U S A. 1997; 94(24):13187-92. PMC: 24284. DOI: 10.1073/pnas.94.24.13187. View

Shi H, Xiao C, Zhong D, Qin S, Liu Y, Liang G . Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics. Am J Respir Crit Care Med. 1998; 157(1):204-9. DOI: 10.1164/ajrccm.157.1.9703027. View

Broide D, Sullivan S, Gifford T, Sriramarao P . Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol. 1998; 18(2):218-25. DOI: 10.1165/ajrcmb.18.2.2829. View

Palframan R, Collins P, Williams T, Rankin S . Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood. 1998; 91(7):2240-8. View

Okada S, Hagan J, Kato M, Hunt L, Gleich G, Kita H . Lidocaine and its analogues inhibit IL-5-mediated survival and activation of human eosinophils. J Immunol. 1998; 160(8):4010-7. View

Matsumoto K, Schleimer R, Bickel C, Beck L, Bochner B . CD44 and CD69 represent different types of cell-surface activation markers for human eosinophils. Am J Respir Cell Mol Biol. 1998; 18(6):860-6. DOI: 10.1165/ajrcmb.18.6.3159. View

Gonzalo J, Lloyd C, Wen D, Albar J, Wells T, Proudfoot A . The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med. 1998; 188(1):157-67. PMC: 2525544. DOI: 10.1084/jem.188.1.157. View

Minshall E, Schleimer R, Cameron L, Minnicozzi M, Egan R, Gutierrez-Ramos J . Interleukin-5 expression in the bone marrow of sensitized Balb/c mice after allergen challenge. Am J Respir Crit Care Med. 1998; 158(3):951-7. DOI: 10.1164/ajrccm.158.3.9709114. View

Palframan R, Collins P, Severs N, Rothery S, Williams T, Rankin S . Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med. 1998; 188(9):1621-32. PMC: 2212511. DOI: 10.1084/jem.188.9.1621. View

10.

Gharaee-Kermani M, Phan S . The role of eosinophils in pulmonary fibrosis (Review). Int J Mol Med. 1998; 1(1):43-53. View

11.

Yamanaka R, Barlow C, Wynshaw-Boris A, Xanthopoulos K . CCAAT/enhancer binding proteins are critical components of the transcriptional regulation of hematopoiesis (Review). Int J Mol Med. 1998; 1(1):213-21. DOI: 10.3892/ijmm.1.1.213. View

12.

Seminario M, Saini S, MacGlashan Jr D, Bochner B . Intracellular expression and release of Fc epsilon RI alpha by human eosinophils. J Immunol. 1999; 162(11):6893-900. View

13.

Kita H, Kaneko M, Bartemes K, Weiler D, Schimming A, Reed C . Does IgE bind to and activate eosinophils from patients with allergy?. J Immunol. 1999; 162(11):6901-11. View

14.

Mishra A, Hogan S, Lee J, Foster P, Rothenberg M . Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest. 1999; 103(12):1719-27. PMC: 408388. DOI: 10.1172/JCI6560. View

15.

Munitz A, Bachelet I, Levi-Schaffer F . Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J Allergy Clin Immunol. 2006; 118(5):1082-9. DOI: 10.1016/j.jaci.2006.07.041. View

16.

Main S, Handy R, Wilton J, Smith S, Williams L, Fou L . A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy. J Pharmacol Exp Ther. 2006; 319(3):1395-404. DOI: 10.1124/jpet.106.110734. View

17.

Stein M, Collins M, Villanueva J, Kushner J, Putnam P, Buckmeier B . Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol. 2006; 118(6):1312-9. DOI: 10.1016/j.jaci.2006.09.007. View

18.

Pero R, Borchers M, Spicher K, Ochkur S, Sikora L, Rao S . Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc Natl Acad Sci U S A. 2007; 104(11):4371-6. PMC: 1838609. DOI: 10.1073/pnas.0700185104. View

19.

Meyer M, Beeh K, Beier J, Beyer D, Aydt E, Zahlten R . Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males. Br J Clin Pharmacol. 2006; 63(4):451-8. PMC: 2203253. DOI: 10.1111/j.1365-2125.2006.02775.x. View

20.

von Gunten S, Vogel M, Schaub A, Stadler B, Miescher S, Crocker P . Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. J Allergy Clin Immunol. 2007; 119(4):1005-11. DOI: 10.1016/j.jaci.2007.01.023. View