Expression of APP in the Early Stage of Brain Damage

Overview

Journal Brain Res

Specialty Neurology

Date 1991 Nov 1

PMID 1786548

Citations 21

Authors

T Kawarabayashi

M Shoji

Y Harigaya

H Yamaguchi

S Hirai

Affiliations

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Abstract

We immunocytochemically studied the expression of various epitopes of amyloid beta/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP695 rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.

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