Expression of Perforin and Granzymes in Vivo: Potential Diagnostic Markers for Activated Cytotoxic Cells

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1991 Nov 1

PMID 1786074

Citations 27

Authors

G M Griffiths

C Mueller

Affiliations

Soon will be listed here.

Abstract

Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by cytotoxic T cells and natural killer cells. Here, Gillian Griffiths and Christoph Mueller describe the expression of perforin and granzymes, emphasizing studies in vivo, and discuss the possibility that these proteins are useful diagnostic markers for immune responses involving cytolytic cells.

Citing Articles

Identification of CBPA as a New Inhibitor of PD-1/PD-L1 Interaction.

Wang F, Ye W, He Y, Zhong H, Zhu Y, Han J Int J Mol Sci. 2023; 24(4).

PMID: 36835382 PMC: 9964281. DOI: 10.3390/ijms24043971.

Role of CD8(+) T cells in protection against Leishmania donovani infection in healed Visceral Leishmaniasis individuals.

Kaushal H, Bras-Goncalves R, Negi N, Lemesre J, Papierok G, Salotra P BMC Infect Dis. 2014; 14:653.

PMID: 25471494 PMC: 4258298. DOI: 10.1186/s12879-014-0653-6.

An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT.

Schaft N, Coccoris M, Drexhage J, Knoop C, de Vries I, Adema G Front Immunol. 2013; 4:270.

PMID: 24027572 PMC: 3762364. DOI: 10.3389/fimmu.2013.00270.

Aberrant antigenic expression in extranodal NK/T-cell lymphoma: a multi-parameter study from Thailand.

Pongpruttipan T, Kummalue T, Bedavanija A, Khuhapinant A, Ohshima K, Arakawa F Diagn Pathol. 2011; 6:79.

PMID: 21867533 PMC: 3170575. DOI: 10.1186/1746-1596-6-79.

Characterization of the host immune response in human Ganglia after herpes zoster.

Gowrishankar K, Steain M, Cunningham A, Rodriguez M, Blumbergs P, Slobedman B J Virol. 2010; 84(17):8861-70.

PMID: 20573825 PMC: 2919016. DOI: 10.1128/JVI.01020-10.