Serum 25(OH)-vitamin D Concentration and Risk of Esophageal Squamous Dysplasia

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2007 Sep 15

PMID 17855710

Citations 24

Authors

Christian C Abnet

Wen Chen

Sanford M Dawsey

Wen-Qiang Wei

Mark J Roth

Bing Liu

Ning Lu

Philip R Taylor

You-Lin Qiao

Affiliations

Soon will be listed here.

Abstract

Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer.

Methods: We measured serum 25-hydroxyvitamin D [25(OH)D] concentrations in a cross-sectional analysis of 720 subjects from Linxian, China, a population at high risk for developing esophageal squamous cell carcinoma. All subjects underwent endoscopy and biopsy and were categorized by the presence or absence of histologic squamous dysplasia. We used crude and multivariate-adjusted generalized linear models to estimate the relative risks (RR) and 95% confidence intervals (95% CI) for the association between squamous dysplasia and sex-specific quartiles of serum 25(OH)D concentration.

Results: Two-hundred and thirty of 720 subjects (32%) had squamous dysplasia. Subjects with dysplasia had significantly higher median serum 25(OH)D concentrations than subjects without dysplasia, 36.5 and 31.5 nmol/L, respectively (Wilcoxon two-sample test, P = 0.0004). In multivariate-adjusted models, subjects in the highest compared with the lowest quartiles were at a significantly increased risk of squamous dysplasia (RR, 1.86; 95% CI, 1.35-2.62). Increased risks were similar when examined in men and women separately: men (RR, 1.74; 95% CI, 1.08-2.93); women (RR, 1.96; 95% CI, 1.28-3.18).

Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.

Citing Articles

Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study.

Dong J, Gao M, Li L, Pan X, Chen S, Li J Nutrients. 2023; 15(18).

PMID: 37764860 PMC: 10537352. DOI: 10.3390/nu15184078.

What have we learned from Linxian esophageal cancer etiological studies?.

Wang S, Abnet C, Qiao Y Thorac Cancer. 2019; 10(5):1036-1042.

PMID: 30925028 PMC: 6500974. DOI: 10.1111/1759-7714.13058.

Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Goyal H, Perisetti A, Rahman M, Levin A, Lippi G Dig Dis Sci. 2018; 64(5):1098-1109.

PMID: 30511197 DOI: 10.1007/s10620-018-5400-1.

Five-year single-centre experience of carcinoma of the oesophagus from Blantyre, Malawi.

Chetwood J, Finch P, Kankwatira A, Mallewa J, Gordon M, Masamba L BMJ Open Gastroenterol. 2018; 5(1):e000232.

PMID: 30397505 PMC: 6203015. DOI: 10.1136/bmjgast-2018-000232.

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.

Singhal S, Kapoor H, Subramanian S, Agrawal D, Mittal S J Gastrointest Cancer. 2018; 50(4):867-878.

PMID: 30187205 DOI: 10.1007/s12029-018-0164-6.

References

Tran G, Sun X, Abnet C, Fan J, Dawsey S, Dong Z . Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer. 2004; 113(3):456-63. DOI: 10.1002/ijc.20616. View

Wang G, Abnet C, Shen Q, Lewin K, Sun X, ROTH M . Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut. 2005; 54(2):187-92. PMC: 1774842. DOI: 10.1136/gut.2004.046631. View

M J Roth Y-L Qiao N Rothman J A Tangrea S M Dawsey G-Q Wang S-H Cho D Kang P R Taylor P T Strickland . High urine 1-hydroxypyrene glucuronide concentrations in Linxian, China, an area of high risk for squamous oesophageal cancer. Biomarkers. 2013; 6(5):381-6. DOI: 10.1080/13547500110044780. View

Stolzenberg-Solomon R, Vieth R, Azad A, Pietinen P, Taylor P, Virtamo J . A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res. 2006; 66(20):10213-9. DOI: 10.1158/0008-5472.CAN-06-1876. View

Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G . Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer. 2003; 108(1):104-8. DOI: 10.1002/ijc.11375. View

Boscoe F, Schymura M . Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer. 2006; 6:264. PMC: 1665523. DOI: 10.1186/1471-2407-6-264. View

Abnet C, Qiao Y, Dawsey S, Buckman D, Yang C, Blot W . Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Cancer Causes Control. 2003; 14(7):645-55. DOI: 10.1023/a:1025619608851. View

Mark S, Qiao Y, Dawsey S, Wu Y, Katki H, Gunter E . Prospective study of serum selenium levels and incident esophageal and gastric cancers. J Natl Cancer Inst. 2000; 92(21):1753-63. DOI: 10.1093/jnci/92.21.1753. View

Taylor P, Qiao Y, Abnet C, Dawsey S, Yang C, Gunter E . Prospective study of serum vitamin E levels and esophageal and gastric cancers. J Natl Cancer Inst. 2003; 95(18):1414-6. DOI: 10.1093/jnci/djg044. View

10.

Giovannucci E, Liu Y, Rimm E, Hollis B, Fuchs C, Stampfer M . Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006; 98(7):451-9. DOI: 10.1093/jnci/djj101. View

11.

Kutuzova G, Deluca H . 1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine. Toxicol Appl Pharmacol. 2006; 218(1):37-44. DOI: 10.1016/j.taap.2006.10.005. View

12.

Dawsey S, Fleischer D, Wang G, Zhou B, Kidwell J, Lu N . Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China. Cancer. 1998; 83(2):220-31. View

13.

Dawsey S, Lewin K, Liu F, Wang G, Shen Q . Esophageal morphology from Linxian, China. Squamous histologic findings in 754 patients. Cancer. 1994; 73(8):2027-37. DOI: 10.1002/1097-0142(19940415)73:8<2027::aid-cncr2820730803>3.0.co;2-3. View

14.

Wei W, Abnet C, Lu N, ROTH M, Wang G, Dye B . Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China. Gut. 2005; 54(6):759-63. PMC: 1774536. DOI: 10.1136/gut.2004.062331. View

15.

Ke L . Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90. Int J Cancer. 2002; 102(3):271-4. DOI: 10.1002/ijc.10706. View

16.

Abnet C, Lai B, Qiao Y, Vogt S, Luo X, Taylor P . Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst. 2005; 97(4):301-6. DOI: 10.1093/jnci/dji042. View

17.

Parkin D, Bray F, Devesa S . Cancer burden in the year 2000. The global picture. Eur J Cancer. 2001; 37 Suppl 8:S4-66. DOI: 10.1016/s0959-8049(01)00267-2. View

18.

Shimada T . Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab Pharmacokinet. 2006; 21(4):257-76. DOI: 10.2133/dmpk.21.257. View

19.

Chen W, Dawsey S, Qiao Y, Mark S, Dong Z, Taylor P . Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers. Br J Cancer. 2007; 97(1):123-8. PMC: 2359654. DOI: 10.1038/sj.bjc.6603834. View

20.

Zou X, Taylor P, Mark S, Chao A, Wang W, Dawsey S . Seasonal variation of food consumption and selected nutrient intake in Linxian, a high risk area for esophageal cancer in China. Int J Vitam Nutr Res. 2003; 72(6):375-82. DOI: 10.1024/0300-9831.72.6.375. View