Emerging Roles of Proteases in Tumour Suppression

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2007 Sep 14

PMID 17851543

Citations 324

Authors

Carlos Lopez-Otin

Lynn M Matrisian

Affiliations

Soon will be listed here.

Abstract

Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?

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