Retinoic Acid Enhances Nephron Endowment in Rats Exposed to Maternal Protein Restriction

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2007 Sep 13

PMID 17849154

Citations 18

Authors

John Makrakis

Monika A Zimanyi

M Jane Black

Affiliations

Soon will be listed here.

Abstract

A reduced nephron complement at birth renders the kidney susceptible to renal disease in adulthood. Retinoic acid (RA; the active metabolite of vitamin A) is linked to nephrogenesis in vitro and in vivo. The aim of this study was to determine the effect of administration of retinoic acid in midgestation in rats on nephron endowment in offspring exposed to maternal protein restriction. Rats were fed either a normal-protein diet (NPD) or a low-protein diet (LPD) during pregnancy and lactation. Half of the dams in the LPD group were injected intraperitoneally with retinoic acid (20 mg/kg) during gestation at embryonic day 11.5. At 4 weeks of age, the offspring were anesthetized and perfusion-fixed, and nephron number estimated using unbiased stereological techniques. Body weight and kidney volume was significantly reduced in all LPD offspring. There was a significant 29% reduction in nephron number in the LPD group compared with the NPD offspring, whereas the number of nephrons in kidneys from the LPD + RA offspring was not significantly different compared with controls. In conclusion, administration of a single bolus dose of retinoic acid during midgestation restored nephron endowment to normal in offspring exposed to maternal protein restriction.

Citing Articles

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Fukunaga S, Fujita Y Front Endocrinol (Lausanne). 2023; 14:1120801.

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The impact of intrauterine growth restriction and prematurity on nephron endowment.

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Administration of retinoic acid to pregnant mice increases the number of fetal mouse glomeruli.

Fukunaga S, Ogawa N, Matsumoto A, Ito T, Tanabe K, Otani H Biochem Biophys Rep. 2022; 30:101245.

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