Allele-specific Targeting of MicroRNAs to HLA-G and Risk of Asthma

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2007 Sep 12

PMID 17847008

Citations 179

Authors

Zheng Tan

Glenn Randall

Jihua Fan

Blanca Camoretti-Mercado

Rebecca Brockman-Schneider

Lin Pan

Julian Solway

James E Gern

Robert F Lemanske

Dan Nicolae

Carole Ober

Affiliations

Soon will be listed here.

Abstract

HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.

Citing Articles

Influence of HLA-G 3' Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort.

Rohn H, Elischer F, Larbig L, Jansen S, Schramm S, Otte M HLA. 2024; 104(6):e15799.

PMID: 39711218 PMC: 11664307. DOI: 10.1111/tan.15799.

HLA-G high-expressor 3'UTR markers are linked to gastric cancer development and survival.

Vaquero-Yuste C, Juarez I, Molina-Alejandre M, Molanes-Lopez E, Gutierrez-Calvo A, Lopez-Garcia A Cancer Immunol Immunother. 2024; 74(1):26.

PMID: 39549048 PMC: 11569108. DOI: 10.1007/s00262-024-03771-w.

Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes.

Arumugam T, Adimulam T, Gokul A, Ramsuran V Front Immunol. 2024; 15:1422834.

PMID: 39355248 PMC: 11442197. DOI: 10.3389/fimmu.2024.1422834.

Association of HLA-G 3'UTR polymorphisms with hepatitis B virus infection in Tunisian population.

Laaribi A, Mehri A, Yahia H, Chaouch H, Babay W, Letaief A Immunol Res. 2024; 72(5):1136-1146.

PMID: 38970627 DOI: 10.1007/s12026-024-09516-2.

Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis.

Pan Y, Cengiz R, Kluiver J, Diepstra A, van den Berg A Cancers (Basel). 2024; 16(6).

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References

Rusinov V, Baev V, Minkov I, Tabler M . MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence. Nucleic Acids Res. 2005; 33(Web Server issue):W696-700. PMC: 1160125. DOI: 10.1093/nar/gki364. View

He L, Thomson J, Hemann M, Hernando-Monge E, Mu D, Goodson S . A microRNA polycistron as a potential human oncogene. Nature. 2005; 435(7043):828-33. PMC: 4599349. DOI: 10.1038/nature03552. View

Wu L, Belasco J . Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. Mol Cell Biol. 2005; 25(21):9198-208. PMC: 1265813. DOI: 10.1128/MCB.25.21.9198-9208.2005. View

Ober C, Thompson E . Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol. 2005; 17(6):670-8. DOI: 10.1016/j.coi.2005.09.009. View

Tan Z, Shon A, Ober C . Evidence of balancing selection at the HLA-G promoter region. Hum Mol Genet. 2005; 14(23):3619-28. DOI: 10.1093/hmg/ddi389. View

Vercelli D, Martinez F . The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough. J Allergy Clin Immunol. 2006; 117(6):1303-5. DOI: 10.1016/j.jaci.2006.03.030. View

Clop A, Marcq F, Takeda H, Pirottin D, Tordoir X, Bibe B . A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet. 2006; 38(7):813-8. DOI: 10.1038/ng1810. View

Ober C, Billstrand C, Kuldanek S, Tan Z . The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells. Hum Reprod. 2006; 21(7):1743-8. DOI: 10.1093/humrep/del036. View

Calin G, Croce C . MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6(11):857-66. DOI: 10.1038/nrc1997. View

10.

Abelson J, Kwan K, ORoak B, Baek D, Stillman A, Morgan T . Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005; 310(5746):317-20. DOI: 10.1126/science.1116502. View

11.

Koppelman G, Stine O, Xu J, Howard T, Zheng S, Kauffman H . Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol. 2002; 109(3):498-506. DOI: 10.1067/mai.2002.122235. View

12.

Hoffjan S, Ober C . Present status on the genetic studies of asthma. Curr Opin Immunol. 2002; 14(6):709-17. DOI: 10.1016/s0952-7915(02)00393-x. View

13.

Brennecke J, Hipfner D, Stark A, Russell R, Cohen S . bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 2003; 113(1):25-36. DOI: 10.1016/s0092-8674(03)00231-9. View

14.

Rousseau P, Le Discorde M, Mouillot G, Marcou C, Carosella E, Moreau P . The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol. 2003; 64(11):1005-10. DOI: 10.1016/j.humimm.2003.08.347. View

15.

Johnston R, Hobert O . A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature. 2003; 426(6968):845-9. DOI: 10.1038/nature02255. View

16.

Wright A . The epidemiology of the atopic child: who is at risk for what?. J Allergy Clin Immunol. 2003; 113(1 Suppl):S2-7. DOI: 10.1016/j.jaci.2003.09.050. View

17.

Chen C, Li L, Lodish H, Bartel D . MicroRNAs modulate hematopoietic lineage differentiation. Science. 2003; 303(5654):83-6. DOI: 10.1126/science.1091903. View

18.

Bartel D . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-97. DOI: 10.1016/s0092-8674(04)00045-5. View

19.

Jin P, Zarnescu D, Ceman S, Nakamoto M, Mowrey J, Jongens T . Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci. 2004; 7(2):113-7. DOI: 10.1038/nn1174. View

20.

Wills-Karp M, Ewart S . Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004; 5(5):376-87. DOI: 10.1038/nrg1326. View