» Articles » PMID: 17840698

Ribosomal Protein Conferring Sensitivity to the Antibiotic Spectinomycin in Escherichia Coli

Overview
Journal Science
Specialty Science
Date 1969 Jul 4
PMID 17840698
Citations 46
Authors
Affiliations
Soon will be listed here.
Abstract

Reconstitution of 30S ribosomal particles from 16S ribosomal RNA and total proteins, or from core proteins and split proteins obtained from the ribosomes of strains of Escherichia coli sensitive to and resistant to spectinomycin, shows that the split protein fraction determines the response of polypeptide synthesis in virto to spectinomycin. Reconstitution of active particles in the presence of isolated split proteins allowed the identification of the single split protein responsible for spectinomycin sensitivity.

Citing Articles

Translational protein RpsE as an alternative target for novel nucleoside analogues to treat MDR Enterobacter cloacae ATCC 13047: network analysis and molecular dynamics study.

Debroy R, Ramaiah S World J Microbiol Biotechnol. 2023; 39(7):187.

PMID: 37150764 PMC: 10164620. DOI: 10.1007/s11274-023-03634-z.


Genotoxic Agents Produce Stressor-Specific Spectra of Spectinomycin Resistance Mutations Based on Mechanism of Action and Selection in Bacillus subtilis.

Korry B, Lee S, Chakrabarti A, Choi A, Ganser C, Machan J Antimicrob Agents Chemother. 2021; 65(10):e0089121.

PMID: 34339280 PMC: 8448107. DOI: 10.1128/AAC.00891-21.


Modulation of decoding fidelity by ribosomal proteins S4 and S5.

Agarwal D, Kamath D, Gregory S, OConnor M J Bacteriol. 2014; 197(6):1017-25.

PMID: 25548247 PMC: 4336341. DOI: 10.1128/JB.02485-14.


Further similarities between chloroplast and bacterial ribosomes.

Ellis R Planta. 2014; 91(4):329-35.

PMID: 24500097 DOI: 10.1007/BF00387506.


A novel single amino acid change in small subunit ribosomal protein S5 has profound effects on translational fidelity.

Kirthi N, Roy-Chaudhuri B, Kelley T, Culver G RNA. 2006; 12(12):2080-91.

PMID: 17053085 PMC: 1664723. DOI: 10.1261/rna.302006.