» Articles » PMID: 17784857

Fungal Nucleobase Transporters

Overview
Specialty Microbiology
Date 2007 Sep 6
PMID 17784857
Citations 33
Authors
Affiliations
Soon will be listed here.
Abstract

Early genetic and physiological work in bacteria and fungi has suggested the presence of highly specific nucleobase transport systems. Similar transport systems are now known to exist in algae, plants, protozoa and metazoa. Within the last 15 years, a small number of microbial genes encoding nucleobase transporters have been cloned and studied in great detail. The sequences of several other putative proteins submitted to databases are homologous to the microbial nucleobase transporters but their physiological functions remain largely undetermined. In this review, genetic, biochemical and molecular data are described concerning mostly the nucleobase transporters of Aspergillus nidulans and Saccharomyces cerevisiae, the two model ascomycetes from which the great majority of data come from. It is also discussed as to what is known on the nucleobase transporters of the two most significant pathogenic fungi: Candida albicans and Aspergillus fumigatus. Apart from highlighting how a basic process such as nucleobase recognition and transport operates, this review intends to highlight features that might be applicable to antifungal pharmacology.

Citing Articles

Mutational analysis of Phanerochaete chrysosporium´s purine transporter.

Barraco-Vega M, Sanguinetti M, da Rosa G, Cecchetto G PLoS One. 2024; 19(10):e0313174.

PMID: 39480815 PMC: 11527162. DOI: 10.1371/journal.pone.0313174.


Next-generation AMA1-based plasmids for enhanced heterologous expression in filamentous fungi.

Roux I, Woodcraft C, Sbaraini N, Pepper A, Wong E, Bracegirdle J Microb Biotechnol. 2024; 17(9):e70010.

PMID: 39276061 PMC: 11401059. DOI: 10.1111/1751-7915.70010.


Lethal metabolism of Candida albicans respiratory mutants.

Kane D, Burke Jr B, Diaz M, Wolf C, Fonzi W PLoS One. 2024; 19(4):e0300630.

PMID: 38578754 PMC: 10997084. DOI: 10.1371/journal.pone.0300630.


The last two transmembrane helices in the APC-type FurE transporter act as an intramolecular chaperone essential for concentrative ER-exit.

Pyrris Y, Papadaki G, Mikros E, Diallinas G Microb Cell. 2024; 11:1-15.

PMID: 38225947 PMC: 10788122. DOI: 10.15698/mic2024.01.811.


Conidial Germination Is Dominated by Pathogenicity Factors and Effectors.

Carreon-Anguiano K, Gomez-Tah R, Pech-Balan E, Ek-Hernandez G, De Los Santos-Briones C, Islas-Flores I J Fungi (Basel). 2023; 9(10).

PMID: 37888226 PMC: 10607838. DOI: 10.3390/jof9100970.