Replication of the RNA of Bacteriophage F2

Overview

Journal Science

Specialty Science

Date 1966 Apr 15

PMID 17775172

Citations 22

Authors

H F Lodish

N D Zinder

Affiliations

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Abstract

Events occurring after infection of bacteria with wild-type and a temperature-sensitive mutant phage indicate that there are two enzymatic activities necessary to replicate phage RNA. One converts single strands into double strands, while the other uses double strands to svnthesize viral RNA. The mutant is deficient in the first activity, probably because the mutation is in the gene specifying the requisite enzyme. On the basis of these and other results, a model is presented for the replication of phage RNA.

Citing Articles

The molecular genetics of bacteriophage: the work of Norton Zinder.

Kresge N, Simoni R, Hill R J Biol Chem. 2011; 286(25):e4-5.

PMID: 21830328 PMC: 3121416. DOI: 10.1074/jbc.o111.000244.

Infectious nucleic acids of e. Coli bacteriophages, ix. Sedimentation constants and strand integrity of infectious m12 phage replicative-form RNA.

Francke B, Hofschneider P Proc Natl Acad Sci U S A. 1966; 56(6):1883-90.

PMID: 16591434 PMC: 220205. DOI: 10.1073/pnas.56.6.1883.

The in vitro synthesis of a noninfectious complex containing biologically active viral RNA.

Mills D, Pace N, Spiegelman S Proc Natl Acad Sci U S A. 1966; 56(6):1778-85.

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Maturation defects in temperature-sensitive mutants of Sindbis virus.

Yin F, LOCKART Jr R J Virol. 1968; 2(7):728-37.

PMID: 5723529 PMC: 375681. DOI: 10.1128/JVI.2.7.728-737.1968.

Temperature-sensitive mutants of Sindbis virus: biochemical correlates of complementation.

BURGE B, Pfefferkorn E J Virol. 1967; 1(5):956-62.

PMID: 5630228 PMC: 375374. DOI: 10.1128/JVI.1.5.956-962.1967.