NPM1 Mutations Are More Stable Than FLT3 Mutations During the Course of Disease in Patients with Acute Myeloid Leukemia

Overview

Journal Haematologica

Specialty Hematology

Date 2007 Sep 5

PMID 17768124

Citations 18

Authors

Michela Palmisano

Tiziana Grafone

Emanuela Ottaviani

Nicoletta Testoni

Michele Baccarani

Giovanni Martinelli

Affiliations

Soon will be listed here.

Abstract

NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.

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Somatic mutations precede acute myeloid leukemia years before diagnosis.

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Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A.

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