A QTL Influencing F Cell Production Maps to a Gene Encoding a Zinc-finger Protein on Chromosome 2p15

Overview

Journal Nat Genet

Specialty Genetics

Date 2007 Sep 4

PMID 17767159

Citations 255

Authors

Stephan Menzel

Chad Garner

Ivo Gut

Fumihiko Matsuda

Masao Yamaguchi

Simon Heath

Mario Foglio

Diana Zelenika

Anne Boland

Helen Rooks

Steve Best

Tim D Spector

Martin Farrall

Mark Lathrop

Swee Lay Thein

Affiliations

Soon will be listed here.

Abstract

F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.

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