Glutamate Receptor Subunit Expression in the Rhesus Macaque Locus Coeruleus

Overview

Journal Brain Res

Specialty Neurology

Date 2007 Sep 4

PMID 17765206

Citations 9

Authors

Nigel C Noriega

Vasilios T Garyfallou

Steven G Kohama

Henryk F Urbanski

Affiliations

Soon will be listed here.

Abstract

The locus coeruleus (LC) is a major noradrenergic brain nucleus that regulates states of arousal, optimizes task-oriented decision making, and may also play an important role in modulating the activity of the reproductive neuroendocrine axis. Rodent studies have shown that the LC is responsive to glutamate receptor agonists, and that it expresses various glutamate receptor subunits. However, glutamate receptor subunit expression has not been extensively examined in the primate LC. We previously demonstrated expression of the NR1 NMDA glutamate receptor subunit in the rhesus macaque LC and now extend this work by also examining the expression of non-NMDA (AMPA and kainate) ionotropic glutamate receptor subunits. Using in situ hybridization histochemistry and immunohistochemistry, we confirmed the presence of the obligatory NR1 subunit in the LC. In addition, we demonstrated expression of the AMPA glutamate receptor subunits GluR1, GluR2, and GluR3. More extensive receptor profiling, using rhesus monkey gene microarrays (Affymetrix GeneChip), further corroborated the histological findings and showed expression of mRNA encoding ionotropic glutamate receptor subunits NR2A, NR2D, GluR4, and GluR6, as well as the metabotropic glutamate receptor subunits mGluR1, mGluR3, mGluR4, mGluR5, and mGluR7. These data provide a foundation for future examination of how changes in glutamate receptor composition contribute to the control of primate physiology.

Citing Articles

Subunit-specific expression and function of AMPA receptors in the mouse locus coeruleus.

Kelly L, Brown C, Gibbard A, Jackson T, Swinny J J Anat. 2023; 243(5):813-825.

PMID: 37391270 PMC: 10557397. DOI: 10.1111/joa.13922.

Locus Coeruleus Neurons' Firing Pattern Is Regulated by ERG Voltage-Gated K Channels.

Hasan S, Delicata F, Guasti L, Duranti C, Haidar F, Arcangeli A Int J Mol Sci. 2022; 23(23).

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Dong X, Zhao Z, Hu Y, Lu Y, Liu P, Zhang L Gastric Cancer. 2019; 23(2):260-272.

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Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons.

Mueller A, Krock R, Shepard S, Moore T Cereb Cortex. 2019; 30(1):148-164.

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Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the wistar kyoto rat.

Bruzos-Cidon C, Llamosas N, Ugedo L, Torrecilla M Int J Neuropsychopharmacol. 2015; 18(7):pyu122.

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