Nerve Growth Factor As an Angiogenic Factor

Overview

Journal Microvasc Res

Specialty Cardiology & Vascular Diseases

Date 2007 Sep 4

PMID 17764704

Citations 76

Authors

Beatrice Nico

Domenica Mangieri

Vincenzo Benagiano

Enrico Crivellato

Domenico Ribatti

Affiliations

Soon will be listed here.

Abstract

Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions.

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