Dietary Taurine Supplementation Ameliorates Diabetic Retinopathy Via Anti-excitotoxicity of Glutamate in Streptozotocin-induced Sprague-Dawley Rats

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2007 Sep 1

PMID 17762918

Citations 28

Authors

Xiaoping Yu

Zhaoxia Xu

Mantian Mi

Hongxia Xu

Jundong Zhu

Na Wei

Ka Chen

Qianyong Zhang

Kaihong Zeng

Jian Wang

Fang Chen

Yong Tang

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms. The Sprague-Dawley rats were injected with streptozotocin to establish experimental diabetic model, then fed without or with 1.2% taurine for additional 4-12 weeks. After that, the protective effects of dietary taurine supplementation on diabetic retinopathy were estimated. Our results showed that chronic taurine supplement effectively improved diabetic retinopathy as changes of histopathology and ultrastructure. The supplementation could not lower plasma glucose concentration (P > 0.05), but caused an elevation in taurine content and a decline in levels of glutamate and gamma-aminobutyric acid (GABA) in diabetic retina (P < 0.05). Moreover, chronic taurine supplementation increased glutamate transporter (GLAST) expression (P < 0.05), decreased intermediate filament glial fibrillary acidic protein (GFAP) and N-methyl-D: -aspartate receptor subunit 1 (NR1) expression in diabetic retina (P < 0.05). These results demonstrated that chronic taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in rats.

Citing Articles

Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases.

Lee D, Smith L Life (Basel). 2025; 14(12.

PMID: 39768274 PMC: 11676320. DOI: 10.3390/life14121566.

Protective Effect of Topiramate against Diabetic Retinopathy and Computational Approach Recognizing the Role of NLRP3/IL-1β/TNF-α Signaling.

Mohammad H, Eladl M, AbdelMaogood A, Elshaer R, Ghanam W, Elaskary A Biomedicines. 2023; 11(12).

PMID: 38137423 PMC: 10741203. DOI: 10.3390/biomedicines11123202.

Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models.

Sadikan M, Abdul Nasir N, Lambuk L, Mohamud R, Reshidan N, Low E BMC Ophthalmol. 2023; 23(1):421.

PMID: 37858128 PMC: 10588156. DOI: 10.1186/s12886-023-03155-1.

Taurine: A Source and Application for the Relief of Visual Fatigue.

Duan H, Song W, Guo J, Yan W Nutrients. 2023; 15(8).

PMID: 37111062 PMC: 10142897. DOI: 10.3390/nu15081843.

The role of taurine in male reproduction: Physiology, pathology and toxicology.

Li Y, Peng Q, Shang J, Dong W, Wu S, Guo X Front Endocrinol (Lausanne). 2023; 14:1017886.

PMID: 36742382 PMC: 9889556. DOI: 10.3389/fendo.2023.1017886.

References

Imaki H, Neuringer M, Sturman J . Long-term effects on retina of rhesus monkeys fed taurine-free human infant formula. Adv Exp Med Biol. 1996; 403:351-60. DOI: 10.1007/978-1-4899-0182-8_37. View

Diederen R, La Heij E, Deutz N, Kijlstra A, Kessels A, van Eijk H . Increased glutamate levels in the vitreous of patients with retinal detachment. Exp Eye Res. 2006; 83(1):45-50. DOI: 10.1016/j.exer.2005.10.031. View

Ng Y, Zeng X, Ling E . Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats. Brain Res. 2004; 1018(1):66-72. DOI: 10.1016/j.brainres.2004.05.055. View

Pasantes-Morales H, Moran J, FELLMAN J . Hypotaurine uptake by the retina. J Neurosci Res. 1986; 15(1):101-9. DOI: 10.1002/jnr.490150110. View

Yu X, Chen K, Wei N, Zhang Q, Liu J, Mi M . Dietary taurine reduces retinal damage produced by photochemical stress via antioxidant and anti-apoptotic mechanisms in Sprague-Dawley rats. Br J Nutr. 2007; 98(4):711-9. DOI: 10.1017/S0007114507744409. View

Barber A, Antonetti D, Gardner T . Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci. 2000; 41(11):3561-8. View

Obrosova I, Minchenko A, MARINESCU V, Fathallah L, Kennedy A, Stockert C . Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats. Diabetologia. 2001; 44(9):1102-10. DOI: 10.1007/s001250100631. View

Smith S . Diabetic Retinopathy and the NMDA Receptor. Drug News Perspect. 2003; 15(4):226-232. PMC: 3773688. DOI: 10.1358/dnp.2002.15.4.840055. View

Kawasaki K . [Preretinopathic changes in the oscillatory potential in diabetic retina: interpretation and significance]. Nippon Ganka Gakkai Zasshi. 1999; 102(12):813-36. View

10.

Rivas-Arancibia S, Rodriguez A, Zigova T, Willing A, Brown W, Cahill D . Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid. Int J Neurosci. 2001; 108(1-2):55-67. DOI: 10.3109/00207450108986505. View

11.

Di Leo M, Ghirlanda G, Gentiloni Silveri N, Giardina B, Franconi F, Santini S . Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations. Free Radic Res. 2003; 37(3):323-30. DOI: 10.1080/1071576021000055271. View

12.

Peterson W, Miller S . Identification and functional characterization of a dual GABA/taurine transporter in the bullfrog retinal pigment epithelium. J Gen Physiol. 1995; 106(6):1089-122. PMC: 2229302. DOI: 10.1085/jgp.106.6.1089. View

13.

Li Q, Puro D . Diabetes-induced dysfunction of the glutamate transporter in retinal Müller cells. Invest Ophthalmol Vis Sci. 2002; 43(9):3109-16. View

14.

Lieth E, Barber A, Xu B, Dice C, Ratz M, Tanase D . Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes. 1998; 47(5):815-20. DOI: 10.2337/diabetes.47.5.815. View

15.

Rivas-Arancibia S, Willing A, Zigova T, Rodriguez A, Cahill D, Sanberg P . The effects of taurine on hNT neurons transplanted in adult rat striatum. Cell Transplant. 2001; 9(6):751-8. DOI: 10.1177/096368970000900602. View

16.

Di Leo M, Santini S, Gentiloni Silveri N, Giardina B, Franconi F, Ghirlanda G . Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats. Amino Acids. 2004; 27(2):187-91. DOI: 10.1007/s00726-004-0108-2. View

17.

Nandhini A, Thirunavukkarasu V, Anuradha C . Stimulation of glucose utilization and inhibition of protein glycation and AGE products by taurine. Acta Physiol Scand. 2004; 181(3):297-303. DOI: 10.1111/j.1365-201X.2004.01287.x. View

18.

Doi M, Ma N, Goto R, Semba R, Uji Y . Immunohistochemical localization of amino acids in the diabetic retina of Goto-Kakizaki rats. Ophthalmic Res. 2002; 34(3):139-45. DOI: 10.1159/000063657. View

19.

Lieth E, LaNoue K, Antonetti D, Ratz M . Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group. Exp Eye Res. 2000; 70(6):723-30. DOI: 10.1006/exer.2000.0840. View

20.

Honda M, Inoue M, Okada Y, Yamamoto M . Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. Kobe J Med Sci. 1998; 44(1):1-8. View