Osteoclast Ultrastructure in Paget's Disease

Overview

Journal Calcif Tissue Res

Publisher Springer

Date 1976 Apr 20

PMID 177153

Citations 20

Authors

A Rebel

K Malkani

M Basle

C Bregeon

Affiliations

Soon will be listed here.

Abstract

The ultrastructural study of osteoclasts in biopsies from 12 patients with Paget's disease reveals several cytological anomalies. In Particular, nuclear inclusions, consisting essentially of striated filaments about 150 A in diameter, often organized in bundles and sometimes in paracrystalline arrays, appear to be specific to the disease. Morphologically, the inclusions are remarkably similar to those observed in various cases of viral attack, and the hypothesis of the action of a possible external agent in Paget's disease cannot be ruled out.

Citing Articles

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation.

Miyagawa K, Tenshin H, Mulcrone P, Delgado-Calle J, Subler M, Windle J JCI Insight. 2023; 8(14).

PMID: 37338990 PMC: 10443794. DOI: 10.1172/jci.insight.159838.

Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo.

Miyagawa K, Ohata Y, Delgado-Calle J, Teramachi J, Zhou H, Dempster D JCI Insight. 2020; 5(6).

PMID: 32078587 PMC: 7213785. DOI: 10.1172/jci.insight.133113.

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease.

Teramachi J, Nagata Y, Mohammad K, Inagaki Y, Ohata Y, Guise T J Clin Invest. 2016; 126(3):1012-22.

PMID: 26878170 PMC: 4767344. DOI: 10.1172/JCI82012.

Emerging strategies and therapies for treatment of Paget's disease of bone.

Michou L, Brown J Drug Des Devel Ther. 2011; 5:225-39.

PMID: 21607019 PMC: 3096538. DOI: 10.2147/DDDT.S11306.

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone.

Menaa C, Reddy S, Kurihara N, Maeda H, Anderson D, Cundy T J Clin Invest. 2000; 105(12):1833-8.

PMID: 10862799 PMC: 378510. DOI: 10.1172/JCI9133.

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