Factors in the Pathophysiology of the Liver Ischemia-reperfusion Injury

Overview

Journal J Surg Res

Specialty General Surgery

Date 2007 Aug 21

PMID 17707862

Citations 135

Authors

Eduardo E Montalvo-Jave

Tomas Escalante-Tattersfield

Jose A Ortega-Salgado

Enrique Pina

David A Geller

Affiliations

Soon will be listed here.

Abstract

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling events contributing to local hepatocellular damage are diverse and complex and involve the interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines, reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The purpose of this review article was to summarize the factors that contribute to the pathophysiology of hepatic ischemia-reperfusion injury.

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