Management of Metastatic Melanoma Patients with Brain Metastases

Overview

Journal Curr Oncol Rep

Publisher Current Science

Specialty Oncology

Date 2007 Aug 21

PMID 17706170

Citations 7

Authors

Martin Majer

Wolfram E Samlowski

Affiliations

Soon will be listed here.

Abstract

Brain metastases seem to be an almost inevitable complication in patients with metastatic melanoma. Except for the rare patients who can undergo successful surgical resection of brain metastases, current management strategies do not appear adequate and result in a poor outcome (median survival, 2-4 months). In recent small series, stereotactic radiosurgery or gamma-knife treatment has suggested improvement in local control compared with whole brain radiation therapy. We have recently shown prolonged survival (11.1 months) using a multimodality treatment approach in 44 sequential patients with melanoma brain metastases. A subsequent study demonstrated that the outcome of biochemotherapy for metastatic melanoma is not affected by the presence or absence of brain metastases. Our results suggest that the outcome of patients with melanoma brain metastases can be improved using a multidisciplinary management strategy.

Citing Articles

Local control of melanoma brain metastases treated with stereotactic radiosurgery.

Bagshaw H, Ly D, Suneja G, Jensen R, Shrieve D J Radiosurg SBRT. 2018; 4(3):181-190.

PMID: 29296443 PMC: 5658801.

High frequency of brain metastases after adjuvant therapy for high-risk melanoma.

Samlowski W, Moon J, Witter M, Atkins M, Kirkwood J, Othus M Cancer Med. 2017; 6(11):2576-2585.

PMID: 28994212 PMC: 5673911. DOI: 10.1002/cam4.1223.

Current treatment options of brain metastases and outcomes in patients with malignant melanoma.

Nowak-Sadzikowska J, Walasek T, Jakubowicz J, Blecharz P, Reinfuss M Rep Pract Oncol Radiother. 2016; 21(3):271-7.

PMID: 27601961 PMC: 5002030. DOI: 10.1016/j.rpor.2015.12.001.

Stereotactic radiosurgery for brain metastases from malignant melanoma.

Christ S, Mahadevan A, Floyd S, Lam F, Chen C, Wong E Surg Neurol Int. 2015; 6(Suppl 12):S355-65.

PMID: 26392919 PMC: 4553636. DOI: 10.4103/2152-7806.163315.

Optimal management of metastatic melanoma: current strategies and future directions.

Batus M, Waheed S, Ruby C, Petersen L, Bines S, Kaufman H Am J Clin Dermatol. 2013; 14(3):179-94.

PMID: 23677693 PMC: 3913474. DOI: 10.1007/s40257-013-0025-9.

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