A Novel Analgesic Pyrazine Derivative from the Leaves of Croton Tiglium L

Overview

Journal J Asian Nat Prod Res

Publisher Informa Healthcare

Specialties Biology
Chemistry

Date 2007 Aug 19

PMID 17701561

Citations 8

Authors

Xin-An Wu

Yi-Min Zhao

Neng-Jiang Yu

Affiliations

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Abstract

A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice.

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