Ontogenic Growth of the Haemopoietic Stem Cell Pool in Humans

Overview

Journal Proc Biol Sci

Specialty Biology

Date 2007 Aug 10

PMID 17686727

Citations 8

Authors

David Dingli

Jorge M Pacheco

Affiliations

Soon will be listed here.

Abstract

Recently, the size of the active stem cell pool has been predicted to scale allometrically with the adult mass of mammalian species with a 3/4 power exponent, similar to what has been found to occur for the resting metabolic rate across species. Here we investigate the allometric scaling of human haemopoietic stem cells (HSCs) during ontogenic growth and predict a linear scaling with body mass. We also investigate the allometric scaling of resting metabolic rate during growth in humans and find a linear scaling with mass similar to that of the haemopoietic stem cell pool. Our findings suggest a common underlying organizational principle determining the linear scaling of both the stem cell pool and resting metabolic rate with mass during ontogenic growth within the human species, combined with a 3/4 scaling with adult mass across mammalian species. It is possible that such common principles remain valid for haemopoiesis in other mammalian species.

Citing Articles

Growing and aging of hematopoietic stem cells.

Udroiu I, Sgura A World J Stem Cells. 2021; 13(6):594-604.

PMID: 34249229 PMC: 8246248. DOI: 10.4252/wjsc.v13.i6.594.

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria.

Mon Pere N, Lenaerts T, Pacheco J, Dingli D PLoS Comput Biol. 2018; 14(6):e1006133.

PMID: 29912864 PMC: 6023248. DOI: 10.1371/journal.pcbi.1006133.

Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics.

Risitano A, Selleri C Transl Med UniSa. 2014; 8:1-3.

PMID: 24778992 PMC: 4000457.

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.

Werner B, Dingli D, Traulsen A J R Soc Interface. 2013; 10(85):20130349.

PMID: 23740488 PMC: 4043170. DOI: 10.1098/rsif.2013.0349.

Global dynamics of hematopoietic stem cells and differentiated cells in a chronic myeloid leukemia model.

Ainseba B, Benosman C J Math Biol. 2010; 62(6):975-97.

PMID: 20717678 DOI: 10.1007/s00285-010-0360-x.

References

Reya T, Morrison S, Clarke M, Weissman I . Stem cells, cancer, and cancer stem cells. Nature. 2001; 414(6859):105-11. DOI: 10.1038/35102167. View

Wang J, Dick J . Cancer stem cells: lessons from leukemia. Trends Cell Biol. 2005; 15(9):494-501. DOI: 10.1016/j.tcb.2005.07.004. View

Dingli D, Traulsen A, Pacheco J . Stochastic dynamics of hematopoietic tumor stem cells. Cell Cycle. 2007; 6(4):461-6. DOI: 10.4161/cc.6.4.3853. View

Dingli D, Pacheco J . Allometric scaling of the active hematopoietic stem cell pool across mammals. PLoS One. 2006; 1:e2. PMC: 1762381. DOI: 10.1371/journal.pone.0000002. View

Raes A, Van Aken S, Craen M, Donckerwolcke R, Walle J . A reference frame for blood volume in children and adolescents. BMC Pediatr. 2006; 6:3. PMC: 1434736. DOI: 10.1186/1471-2431-6-3. View

Moore K, Lemischka I . Stem cells and their niches. Science. 2006; 311(5769):1880-5. DOI: 10.1126/science.1110542. View

Glazier D . Beyond the '3/4-power law': variation in the intra- and interspecific scaling of metabolic rate in animals. Biol Rev Camb Philos Soc. 2005; 80(4):611-62. DOI: 10.1017/S1464793105006834. View

WEST G, Brown J, Enquist B . A general model for ontogenetic growth. Nature. 2001; 413(6856):628-31. DOI: 10.1038/35098076. View

West G, Woodruff W, Brown J . Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proc Natl Acad Sci U S A. 2002; 99 Suppl 1:2473-8. PMC: 128563. DOI: 10.1073/pnas.012579799. View

10.

Abkowitz J, Catlin S, McCallie M, Guttorp P . Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. Blood. 2002; 100(7):2665-7. DOI: 10.1182/blood-2002-03-0822. View

11.

Gordon M, Lewis J, Marley S . Of mice and men...and elephants. Blood. 2002; 100(13):4679-80. DOI: 10.1182/blood-2002-08-2517. View

12.

Banavar J, Damuth J, Maritan A, Rinaldo A . Ontogenetic growth: Modelling universality and scaling. Nature. 2002; 420(6916):626; discussion 626-7. DOI: 10.1038/420626a. View

13.

McCarthy K . Marrow frequency of rat long-term repopulating cells: evidence that marrow hematopoietic stem cell concentration may be inversely proportional to species body weight. Blood. 2003; 101(9):3431-5. DOI: 10.1182/blood-2002-10-3026. View

14.

Dick J . Stem cells: Self-renewal writ in blood. Nature. 2003; 423(6937):231-3. DOI: 10.1038/423231a. View

15.

. Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation. World Health Organ Tech Rep Ser. 1985; 724:1-206. View

16.

Castriota-Scanderbeg A, Pedrazzi G, Mercadanti M, Stapane I, Butturini A, Izzi G . Normal values of total reticulocytes and reticulocyte subsets in children and young adults. Haematologica. 1992; 77(4):363-4. View

17.

Uchida N, Fleming W, Alpern E, Weissman I . Heterogeneity of hematopoietic stem cells. Curr Opin Immunol. 1993; 5(2):177-84. DOI: 10.1016/0952-7915(93)90002-a. View

18.

Morrison S, Uchida N, Weissman I . The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol. 1995; 11:35-71. DOI: 10.1146/annurev.cb.11.110195.000343. View

19.

WEST G, Brown J, Enquist B . The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science. 1999; 284(5420):1677-9. DOI: 10.1126/science.284.5420.1677. View

20.

Von Bertalanffy L . Quantitative laws in metabolism and growth. Q Rev Biol. 1957; 32(3):217-31. DOI: 10.1086/401873. View