» Articles » PMID: 17682394

[Steroid Compounds from the Far East Starfish Pteraster Obscurus and the Ophiura Asteronyx Loveni]

Overview
Journal Bioorg Khim
Date 2007 Aug 9
PMID 17682394
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Seven sulfated polyhydroxysteroids were isolated from the Far East starfish Pteraster obscurus and the ophiura (snake star) Asteronyx loveni (collected in the Sea of Okhotsk) and characterized: disodium and sodium salts of (20R)-24-methyl-2beta-hydroxycholesta-5,24(28)-diene-3alpha,21-diyl disulfate, (20R)-5alpha-cholestane-3beta,21-diyl disulfate, (20R)-3beta-hydroxy-5alpha-cholestan-21-yl sulfate, (20R)-cholest-5-ene-3beta,21-diyl disulfate, (20R)-2beta-hydroxycholest-5-ene-3alpha,21-diyl disulfate, (20R)-cholest-5-en-3beta-yl sulfate, and (20R)-5alpha-cholestan-3beta-yl sulfate. The first four compounds turned out to be new, whereas the others were identical to the known compounds. Structures of the isolated steroids were identified by two-dimensional NMR spectroscopy and other physicochemical methods. The compounds isolated from starfish are structurally similar to typical ophiuroid metabolites, which support the opinion of some taxonomists that starfish and ophiuroids are phylogenetically related classes.

Citing Articles

Antioxidant and anticholinesterase properties of and venoms from the Persian Gulf.

Dehghani H, Rashedinia M, Mohebbi G, Vazirizadeh A, Baghban N Front Chem. 2024; 11:1332921.

PMID: 38235395 PMC: 10791789. DOI: 10.3389/fchem.2023.1332921.


Fatty Acids of Echinoderms: Diversity, Current Applications and Future Opportunities.

Zhukova N Mar Drugs. 2023; 21(1).

PMID: 36662194 PMC: 9865275. DOI: 10.3390/md21010021.


Disulfated Ophiuroid Type Steroids from the Far Eastern Starfish and Their Cytotoxic Activity on the Models of 2D and 3D Cultures.

Kicha A, Kalinovsky A, Malyarenko T, Malyarenko O, Ermakova S, Popov R Mar Drugs. 2022; 20(3).

PMID: 35323463 PMC: 8951248. DOI: 10.3390/md20030164.